Evidence map›Paper›PMID 39763189›Full record

ArticleScience progress

Time-Course physiopathology of

Leonel Montealegre-Sánchez, Mikael A Lima, Alejandro Montoya-Gómez, Luis Solano-Redondo, Dayara O Silva, Karuza M Alves Pereira, Mario R Lima Mota, Edilberto Rocha Silveira, Nilce Viana Gramosa Pompeu de Sousa Brasil, Elenilson G Alves Filho and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Brief history of ophidiology and ophidism in Colombia.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Leonel Montealegre-SánchezGrupo de Nutrición, Facultad de Salud, Universidad del Valle, Cali, Colombia.ORCID 0000-0001-7057-717X
Mikael A LimaDepartamento de Fisiologia e Farmacologia - Laboratório de Toxinologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
Alejandro Montoya-GómezGrupo de Nutrición, Facultad de Salud, Universidad del Valle, Cali, Colombia.
Luis Solano-RedondoGrupo de Nutrición, Facultad de Salud, Universidad del Valle, Cali, Colombia.
Dayara O SilvaDepartamento de Fisiologia e Farmacologia - Laboratório de Toxinologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
Karuza M Alves PereiraDepartamento de Morfologia, Universidade Federal do Ceará, Fortaleza, Brazil.
Mario R Lima MotaDepartamento de Clínica Odontológica, Universidade Federal do Ceará, Fortaleza, Brazil.
Edilberto Rocha SilveiraDepartamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Brazil.
Nilce Viana Gramosa Pompeu de Sousa BrasilDepartamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza, Brazil.
Elenilson G Alves FilhoDepartamento de Engenharia Química, Universidade Federal do Ceará, Fortaleza, Brazil.
Alexandre HavtDepartamento de Fisiologia e Farmacologia - Laboratório de Toxinologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
Eliécer Jiménez-CharrisGrupo de Nutrición, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe expansion of human activities in northern Colombia has increased human-snake encounters, particularly with venomous

methodsVenom was inoculated in the gastrocnemius muscles of Swiss Webster mice, and blood, urine, and tissue samples were taken at different times to evaluate lethality and biochemical markers of renal function and oxidative stress.

resultsThis study reports the first intramuscular LD DISCUSSION: Compensatory mechanisms in response to oxidative stress and tissue damage induced by the venom were evident in the envenomed mice over the evaluated time. However, histological analysis revealed evidence of pro-inflammatory processes occurring only at early times. Metabolomic analyses of urine samples identified taurine as a potential early biomarker of elevated oxidative stress and protein and creatinine levels.

conclusions

Indexed as

Oxidative StressSnake BitesAnimalsBiomarkersKidneyLethal Dose 50MaleMiceMuscle, SkeletalViperidaeBiomarkerskidney injuryophidismoxidative stressphysiopathological alterationssnakebite envenomingViperidae

Identifiers

PMID39763189
PMCPMC11705321

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.