Evidence map›Paper›PMID 39763159›Full record

ArticleAmerican journal of epidemiology2025

Evaluating bias in electronic health record data: using agent-based models to examine whether geographic disparities in community-acquired methicillin-resistant Staphylococcus aureus are due to differential health care-seeking behaviors.

Brittany L Morgan Bustamante, Jose Pablo Gomez-Vazquez, Carlos Gonzalez Crespo, Larissa May, Laura Fejerman, Beatriz Martínez-López

Abstract read
In one paragraph

Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brittany L Morgan BustamanteEnvironmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, CA 4720, United States.ORCID 0000-0002-0280-0904
Jose Pablo Gomez-VazquezCenter for Animal Disease Modeling and Surveillance, Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States.ORCID 0000-0002-6712-0029
Carlos Gonzalez CrespoCenter for Animal Disease Modeling and Surveillance, Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States.ORCID 0000-0003-4312-0398
Larissa MayEmergency Medicine, School of Medicine, University of California, Davis, Davis, CA 95817, United States.
Laura FejermanPublic Health Sciences, School of Medicine, University of California, Davis, Davis, CA 95616, United States.
Beatriz Martínez-LópezCenter for Animal Disease Modeling and Surveillance, Department of Veterinary Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, Davis, CA 95616, United States.

Funding

Advancing Fungal Disease Epidemiology through Multilevel Modeling and Data IntegrationK01AI190048 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Brittany Lauren Morgan Bustamante · 2025 to 2026
$396k
NIAID NIH HHS K01 AI190048
6 · The paper itself

Abstract

Electronic health records (EHRs) are increasingly used in public health research. However, biases may exist when using EHRs due to whether someone is captured in the data. Assessing the impact of bias in generating disparities identified with EHR data is difficult because information about health care-seeking behaviors is not included in the record. We developed an agent-based model (ABM) to simulate the health care-seeking behavior for community-acquired methicillin-resistant Staphylococcus aureus infection in a subregion of California. The ABM assumed no difference in prevalence across the study area. We modeled the health care-seeking process to see if geographic differences in prevalence would emerge from the ABM when only looking at those who sought treatment, matching empirical data. The ABM reproduced prevalence in observed data for 9 of the 21 geographies. Simulated differences in prevalence across geographies did not reach the magnitude in observed data, and spatial patterns had low to moderate agreement. Our results suggest that geographic disparities in the methicillin-resistant Staphylococcus aureus prevalence previously identified in California EHR data may be due to determinants beyond bias and health care-seeking behaviors. Future studies could adapt this model for other health outcomes by adjusting the health care-seeking behavior parameters and modifying the disease progression process. This article is part of a Special Collection on Cross-National Gerontology.

Indexed as

Community-Acquired InfectionsElectronic Health RecordsMethicillin-Resistant Staphylococcus aureusPatient Acceptance of Health CareStaphylococcal InfectionsBiasCaliforniaFemaleHumansMalePrevalenceagent-based modelbias analysisCA-MRSAEHR disparitiesgeographic disparities

Identifiers

PMID39763159
PMCPMC12671960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.