ArticleMedicine and science in sports and exercise2025
Acute and Lifelong Endurance Exercise Yields Differential Effects During Circadian Disruption in Mice.
Article in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionCircadian rhythms are responsible for physiological and behavioral processes coordinated in a 24-h cycle. We investigated whether untimed, long-term voluntary wheel access mitigated circadian disruption and facilitated re-entrainment.
methodsThirty-five C57Bl/6J mice ( n = 21 males, n = 14 females) were used in this experiment. Long-term exercised (LTEx) mice ran from 3 wk to 12 months of age. At 12 months, animals were circadian disrupted for 14 d and then re-entrained for 7 d. Long-term sedentary (LTSed) animals were disrupted but had no access to a wheel. Another long-term sedentary group had access to a wheel only during disruption (LTSed+Ex). SubCue data loggers were used to track internal rhythm of core body temperature (Tb). RNA was extracted from skeletal muscle and RT-qPCR was used to analyze gene expression.
resultsOverall, all three experimental groups had an initial entrained period lengths of ~24 h at baseline. There was a main effect of time ( P = 0.012), treatment ( P = 0.005), and time-treatment interaction ( P = 0.033) from baseline to disruption. A post hoc analysis within-group one-way ANOVA showed no difference between baseline and disruption period lengths in the LTSed+Ex treatment, yet a difference from baseline to disruption in LTSed and LTEx. Lastly, there is a difference in entrained period lengths between all three treatment groups at the re-entrainment time point ( P = 0.026) with a difference in change between disruption and re-entrainment with LTEx being lower than LTSed+Ex.
conclusionsOur results suggest that acute-like exercise during circadian disruption aided in mitigating circadian disruption. When all treatment groups were re-entrained back to a normal rhythm, the LTEx animals that had access to a wheel before, during, and after disruption had period lengths closest to baseline values.
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