ArticleMicrobiome2025
Regional antimicrobial resistance gene flow among the One Health sectors in China.
Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A dual-marker approach for forensic age prediction: integrating the salivary microbiome and antibiotic resistome.International journal of legal medicine · 2026Article
- Source-Resolved Wastewater Metagenomics Reveals Distinct Resistome and Virulome Landscapes Across an Urban Wastewater Continuum.Antibiotics (Basel, Switzerland) · 2026Article
- Genomic epidemiology and antimicrobial resistance of non-typhoidal Salmonella from retail meats in Beijing, China: implications for foodborne transmission and phage susceptibility.JAC-antimicrobial resistance · 2026Article
- Antimicrobial resistance and genomic characteristics of bovine Escherichia coli from five northern provinces of China.BMC genomics · 2026Article
- Novel plasmid pCM3 harboring themLife · 2026Article
- Temperature Elevation Alters the Gut Antibiotic Resistome and Carbohydrate-Active Enzymes in the Desert LizardMicroorganisms · 2026Article
- Tick-vectored mobilization of antibiotic resistance genes: transboundary dissemination across wildlife-livestock-vector-environment interfaces.NPJ biofilms and microbiomes · 2026Article
- Phenotypic resistance profiles and resistome variations between endophytic and epiphytic bacteria in apple fruits.Environmental microbiome · 2026Article
- Dietary supplementation with allicin enhances growth performance and antioxidant capacity, and reduces gut pathogens and antibiotic resistance genes in Trachidermus fasciatus.Fish physiology and biochemistry · 2026Article
- Diet and environmental factors jointly drive the gut microbiome, resistome, and virulome of urban bats.NPJ biofilms and microbiomes · 2026Article
- Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics.MicrobiologyOpen · 2026Review
- Clinical Significance ofMicroorganisms · 2026Article
- Restaurant occupational exposure affects the profiles of oral and gut pathobiomes and resistomes.Frontiers in microbiology · 2026Article
- The resistome bridge between livestock and workers: novel frameworks for early detection and monitoring of antimicrobial resistance.Frontiers in public health · 2026Review
- From surveillance to intelligence: a scoping review of machine learning for antimicrobial resistance surveillance intelligence across One Health.Frontiers in public health · 2026Article
- Global landscape of antibiotic resistance genes in the human gut microbiome metagenome-assembled genomes.BMC microbiology · 2025Article
- Xenobiotics and Broiler Microbiota: Molecular Insights into Bacterial Antimicrobial Resistance and Food Safety Implications for Human Health.Journal of xenobiotics · 2025Review
- Celebrating three years ofScience in One Health · 2025Article
- One health approach unravels worrying antimicrobial resistance patterns: A cross-sectional study in Kisii, Kenya.PloS one · 2025Article
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Authors and funding
22 authors.
Funding
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Abstract
backgroundAntimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.
resultsIn this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples. A total of 40 ARG types and 743 ARG subtypes were identified, with a predominance of multidrug resistance genes. Compared with microbes from human fecal samples, those from food and environmental samples showed a significantly higher load of ARGs. We revealed that dietary habits and occupational exposure significantly affect ARG abundance. Pseudomonadota, particularly Enterobacteriaceae, were identified as the main ARG carriers shaping the resistome. The resistome in food samples was found more affected by mobile genetic elements (MGEs), whereas in environmental samples, it was more associated with the microbial composition. We evidenced that horizontal gene transfer (HGT) mediated by plasmids and phages, together with strain transmission, particularly those associated with the Enterobacteriaceae members, drive regional ARG flow. Lifestyle, dietary habits, and occupational exposure are all correlated with ARG dissemination and flies and food are important potential sources of ARGs to humans. The widespread mobile carbapenemase gene, OXA-347, carried by non-Enterobacteriaceae bacteria in the human gut microbiota, requires particular attention. Finally, we showed that machine learning models based on microbiome profiles were effective in predicting the presence of carbapenem-resistant strains, suggesting a valuable approach for AMR surveillance.
conclusionsOur study provides a full picture of regional ARG transmission among the One Health sectors in a county-level city in China, which facilitates a better understanding of the complex routes of ARG transmission and highlights new points of focus for AMR surveillance and control. Video Abstract.
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