Evidence map›Paper›PMID 39762993›Full record

ArticleAddiction science & clinical practice2025

Buprenorphine and postpartum contraception utilization among people with opioid use disorder: a multi-state analysis.

Kevin Y Xu, Jennifer K Bello, Joanna Buss, Hendrée E Jones, Laura J Bierut, Dustin Stwalley, Hannah S Szlyk, Caitlin E Martin, Jeannie C Kelly, Ebony B Carter and 2 more

Erratum issuedAbstract read
In one paragraph

Article in Addiction science & clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kevin Y Xu *Health and Behavior Research Center, Division of Addiction Science, Prevention and Treatment, Department of Psychiatry, Renard Hospital 3007A, Washington University School of Medicine, 4940 Children's Place, Saint Louis, MO, 63110, USA. xukeviny@wustl.edu.
Jennifer K Bello *Departments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.
Joanna BussInstitute for Informatics, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Hendrée E JonesDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Laura J BierutHealth and Behavior Research Center, Division of Addiction Science, Prevention and Treatment, Department of Psychiatry, Renard Hospital 3007A, Washington University School of Medicine, 4940 Children's Place, Saint Louis, MO, 63110, USA.
Dustin StwalleyInstitute for Informatics, Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA.
Hannah S SzlykHealth and Behavior Research Center, Division of Addiction Science, Prevention and Treatment, Department of Psychiatry, Renard Hospital 3007A, Washington University School of Medicine, 4940 Children's Place, Saint Louis, MO, 63110, USA.
Caitlin E MartinDepartment of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Jeannie C KellyDivision of Maternal-Fetal Medicine & Ultrasound, Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA.
Ebony B CarterDepartment of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Elizabeth E Krans *Department of Obstetrics, Gynecology & Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Richard A Grucza *Departments of Family and Community Medicine and Health and Clinical Outcomes Research, Saint Louis University School of Medicine, Saint Louis, MO, USA.

Funding

Washington University Career Development Program in Drug Abuse and AddictionK12DA041449 · NIDA · WASHINGTON UNIVERSITY · PI Laura J. Bierut, Patricia A Cavazos-Rehg · 2017 to 2026
$4.2M
A Preconception Health Intervention to Reduce Substance Exposed Pregnancies among Incarcerated WomenK23DA053433 · NIDA · SAINT LOUIS UNIVERSITY · PI Jennifer Bello Kottenstette · 2022 to 2026
$873k
NIDA NIH HHS K12 DA041449NIDA NIH HHS K23 DA053433NIDA NIH HHS NIH K12 DA041449Washington University in St. Louis CADRA Grant
6 · The paper itself

Abstract

backgroundThe postpartum period provides an opportunity for birthing people with opioid use disorder (OUD) to consider their future reproductive health goals. However, the relationship between the use of medication for opioid use disorder (MOUD) and contraception utilization is not well understood. We used multistate administrative claims data to compare contraception utilization rates among postpartum people with OUD initiating buprenorphine (BUP) versus no medication (psychosocial services receipt without MOUD (PSY)) in the United States (US).

methodsIn this retrospective cohort study, we analyzed data from the Merative™ MarketScan

resultsOur sample consisted of 11,118 postpartum people with OUD. Among those, 3,443 initiated BUP and 7,675 received PSY. By 90 days postpartum, 22.4% (n = 2,487) of the cohort were prescribed contraception (21.5% PSY vs. 24.3% BUP). Among these participants, most received LARC (41.0%), followed by female sterilization (27.3%), the contraceptive injection (17.3%), pills (8.6%), ring (4.7%), and patch (1.0%), Compared to people engaged in PSY, BUP receipt was associated with a greater use of prescribed contraceptive use by 90 days postpartum (adjusted relative risk [aRR] = 1.17[1.07-1.28]), including a modestly greater use of the patch, ring, and pills, (aRR = 1.13[1.08-1.18]), but a modestly lesser use of injection contraception (aRR = 0.95[0.91-0.99]). There was no relationship observed between BUP and LARC use (aRR = 1.00[0.95-1.04]) and female sterilization (aRR = 1.01[0.98-1.06]).

conclusionsOnly 22% of pregnant people with OUD in our cohort used effective or highly-effective postpartum contraception. BUP receipt during pregnancy, relative to PSY, was associated with modestly greater use of prescribed effective contraceptive methods but was not associated with greater use of provider-administered contraceptive methods, such as the contraceptive injection, LARC and female sterilization.

Indexed as

BuprenorphineContraceptionOpiate Substitution TreatmentOpioid-Related DisordersPostpartum PeriodAdolescentAdultContraception BehaviorFemaleHumansLong-Acting Reversible ContraceptionMedicaidPregnancyRetrospective StudiesSterilization, ReproductiveUnited StatesBuprenorphineAdministrative dataBuprenorphineContraceptionLARCOpioid use disorder

Identifiers

PMID39762993
PMCPMC11702041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.