Evidence map›Paper›PMID 39762956›Full record

ArticleWorld journal of surgical oncology2025

Perioperative infections as a prognostic risk factor in hepatocellular carcinoma and cholangiocellular carcinoma: a comparative analysis.

Markus S Jördens, Hannah C Oswald, Lisa Heinrichs, Nathalie Gassmann, Linda Wittig, Tom Luedde, Sven H Loosen, Christoph Roderburg, Wolfram T Knoefel, Georg Fluegen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Markus S JördensDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany. markus.joerdens@med.uni-duesseldorf.de.
Hannah C OswaldDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Lisa HeinrichsDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Nathalie GassmannDepartment for General, Visceral and Pediatric Surgery, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Düsseldorf, Germany.
Linda WittigDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Tom LueddeDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Sven H LoosenDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Christoph RoderburgDepartment for Gastroenterology, Hepatology and Infectious Diseases, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Moorenstr. 5, Düsseldorf, 40225, Germany.
Wolfram T KnoefelDepartment for General, Visceral and Pediatric Surgery, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Düsseldorf, Germany.
Georg FluegenDepartment for General, Visceral and Pediatric Surgery, Medical Faculty, Heinrich Heine University Düsseldorf, University Hospital Düsseldorf, Düsseldorf, Germany.

Funding

Deutsche Forschungsgemeinschaft DFG, FL 865/2-1Dr. Mildred Scheel Stiftung für Krebsforschung 57584079European Research Council 771083
6 · The paper itself

Abstract

backgroundHepatocellular Carcinoma (HCC) and cholangiocellular adenocarcinoma (CCA) are the most common primary liver tumors representing a major global health burden. In early disease stages, tumor resection may provide long-term survival in selected patients. However, morbidity and mortality rates are still relatively high after extended liver surgery with perioperative bacterial infections representing major complications. In this study, we evaluate the impact of perioperative infection on the postoperative overall survival (OS) of patients undergoing resection of HCC or CCA. MATERIAL AND

methodsTwo hundred two patients that received liver surgery for HCC (139) or CCA (63) at our tertiary referral center were included between 2008 and 2020. Infection prior or after surgery was assessed using patient documentation and correlated to patients´ survival rates and other clinical characteristics.

resultsPatients with perioperative infection displayed a significantly impaired OS compared to patients without a documented infection (419 (95% CI: 262-576) days vs. 959 (95% CI: 637-1281) days; log rank X

conclusionPerioperative infection is an important prognostic factor after surgery for HCC but not CCA.

Indexed as

Bile Duct NeoplasmsCarcinoma, HepatocellularCholangiocarcinomaHepatectomyLiver NeoplasmsPostoperative ComplicationsAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk FactorsCCAHCCPerioperative infectionsPrognostic markerSurvival

Identifiers

PMID39762956
PMCPMC11705658

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.