Evidence map›Paper›PMID 39762936›Full record

ArticleAlzheimer's research & therapy2025

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease.

Allison Carles, Aline Freyssin, Sarra Guehairia, Thomas Reguero, Michel Vignes, Hélène Hirbec, Gilles Rubinstenn, Tangui Maurice

Abstract read
In one paragraph

Article in Alzheimer's research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Simvastatin rescues cognitive impairment in an AβNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Towards precision epitopes based vaccine againstBiochemistry and biophysics reports · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Allison CarlesMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.
Aline FreyssinMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.
Sarra GuehairiaMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.
Thomas RegueroMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.
Michel VignesIBMM, Univ Montpellier, CNRS, ENSCM, Montpellier, France.
Hélène HirbecIGF, Univ Montpellier, CNRS, INSERM, Montpellier, France.
Gilles RubinstennReST Therapeutics, Paris, France.
Tangui MauriceMMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France. tangui.maurice@umontpellier.fr.

Funding

SATT AXLR 0682
6 · The paper itself

Abstract

backgroundFluoroethylnormemantine (FENM), a new Memantine (MEM) derivative, prevented amyloid-β[25-35] peptide (Aβ

methodsIn Aβ

resultsDeficits in spontaneous alternation and object recognition in Aβ

conclusionThese data confirmed the neuroprotective potential of FENM in the pharmacological Aβ

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesDisease Models, AnimalMice, TransgenicNeuroprotective AgentsPeptide FragmentsAmyloid beta-Protein PrecursorAnimalsHippocampusMaleMemantineMiceMice, Inbred C57BLAmyloid beta-Peptidesamyloid beta-protein (25-35)Amyloid beta-Protein PrecursorMemantineNeuroprotective AgentsPeptide FragmentsAlzheimer's diseaseDrug infusionFluoroethylnormemantine (FENM)NeuroprotectionNMDA receptor expression

Identifiers

PMID39762936
PMCPMC11702188

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.