Observational studyBMC pulmonary medicine2025
Association between lipid accumulation product and chronic obstructive pulmonary disease: a cross-sectional analysis.
Observational study in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Association between lipid accumulation product and asthma in US adults: evidence from the NHANES 2005-2020.BMC pulmonary medicine · 2026Article
- Inflammatory-metabolic alterations in asthma-COPD overlap compared with COPD: evidence from NHANES and a hospital-based cohort.Frontiers in medicine · 2026Article
- Body roundness index and its role in predicting COPD risk: insights from the English Longitudinal Study of Aging and the health and retirement study.Frontiers in medicine · 2025Article
- Association between visceral adiposity index and chronic obstructive pulmonary disease: A cross-sectional analysis.Science progressArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResearch indicates that obesity can worsen the clinical manifestations of chronic obstructive pulmonary disease (COPD). Timely detection of COPD has the potential to enhance treatment results. This study seeks to investigate the association between a new metabolic indicator, the lipid accumulation product (LAP), and the risk of developing COPD.
methodsThe observational analysis employs data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2007 to 2016. Multivariate logistic regression was used to explore the association between LAP levels and COPD. Further analysis methods included subgroup analysis, smooth curve modeling, and threshold effect evaluation.
resultsWithin the sample of 12,089 individuals, 1,072 were diagnosed with COPD. A positive correlation between LAP levels and COPD risk was identified through logistic regression analysis, even after controlling for potential confounders. The analyses by subgroup showed an enhanced association in participants without hypertension. The smooth curve fitting analysis highlighted particular saturation effects of LAP, with significant inflection points identified at 65.5278 and a P-value of 0.013.
conclusionThis study's findings suggest that elevated LAP levels are associated with an increased risk of COPD. It is suggested that dietary modifications and exercise routines be implemented to mitigate COPD risk in those with higher LAP levels.
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