ArticleBMC genomics2025
The effects of runs-of-homozygosity on pig domestication and breeding.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Genome-Wide Characterisation of the Ashanti Dwarf Pig Within a Global Context: Insights into Diversity, Inbreeding, and Adaptive Signatures.Life (Basel, Switzerland) · 2026Article
- Exploring the Genetic Heritage of the Yucatán Black Hairless Pig: A Comparative Worldwide ROH Study.Veterinary sciences · 2026Article
- Runs of homozygosity reveal candidate genes for economic traits in Danish Large White pigs.Archives animal breeding · 2026Article
- Whole-genome sequencing reveals patterns of runs of homozygosity underlying genetic diversity and selection in domestic rabbits.BMC genomics · 2025Article
- Genome-Wide Association Study Reveals Novel Loci and Candidate Genes for Birth Weight in Pigs.Animals : an open access journal from MDPI · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundSince their domestication, recent inbreeding together with intensive artificial selection and population bottlenecks have allowed the prevalence of deleterious mutations and the increase of runs-of-homozygosity (ROH) in domestic pigs. This makes pigs a good model to understand the genetic underpinnings of inbreeding depression.
resultsHere we integrated a comprehensive dataset comprising 7239 domesticated pigs and wild boars genotyped by single nucleotide polymorphism (SNP) chips, along with phenotypic data encompassing growth, reproduction and disease-associated traits. Our study revealed differential ROH landscapes during domestication and artificial selection of Eurasian pigs. We observed associations between ROH burden and phenotypic traits such as body conformation and susceptibility to diseases like scrotal hernia. By examining associations of whole-genome and regional ROH burden with gene expression, we identified specific genes and pathways affected by inbreeding depression. Associations of regional ROH burden with gene expression also enabled the discovery of novel regulatory elements. Lastly, we inferred recessive lethal mutations by examining depletion of ROH in an inbred population with relatively small sample size, following by fine mapping with sequencing data.
conclusionsThese findings suggested that both phenotypic and genetic variations have been reshaped by inbreeding, and provided insights to the genetic mechanisms underlying inbreeding depression.
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