Evidence map›Paper›PMID 39762731›Full record

ArticleBMC infectious diseases2025

Feasibility and staff acceptability of implementing Xpert HIV-1 viral load point-of-care testing: a pilot study in San Francisco.

Kelvin Moore, Noelle Le Tourneau, Jasmin Alvarez, Santos Rodriguez, Janessa Broussard, Pierre-Cédric Crouch, Jorge Roman, Patricia Defechereux, Jason Bena, Kimberly A Koester and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kelvin MooreUniversity of California, San Francisco, San Francisco, CA, USA.
Noelle Le TourneauUniversity of California, San Francisco, San Francisco, CA, USA.
Jasmin AlvarezSan Francisco AIDS Foundation, San Francisco, CA, USA.
Santos RodriguezSan Francisco AIDS Foundation, San Francisco, CA, USA.
Janessa BroussardUniversity of California, San Francisco, San Francisco, CA, USA.
Pierre-Cédric CrouchUniversity of California, San Francisco, San Francisco, CA, USA.
Jorge RomanUniversity of California, San Francisco, San Francisco, CA, USA.
Patricia DefechereuxGladstone Institutes, San Francisco, CA, USA.
Jason BenaSan Francisco AIDS Foundation, San Francisco, CA, USA.
Kimberly A KoesterUniversity of California, San Francisco, San Francisco, CA, USA.
Lissa MoranUniversity of California, San Francisco, San Francisco, CA, USA.
Christopher PilcherUniversity of California, San Francisco, San Francisco, CA, USA.
Robert GrantUniversity of California, San Francisco, San Francisco, CA, USA.
Katerina A ChristopoulosUniversity of California, San Francisco, San Francisco, CA, USA. katerina.christopoulos@ucsf.edu.

Funding

Mentoring Patient-Oriented Research on Advances to Optimize Engagement in HIV CareK24AI167805 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katerina A Christopoulos · 2022 to 2026
$963k
National Institute of Allergy and Infectious Diseases K24AI167805NIAID NIH HHS K24 AI167805
6 · The paper itself

Abstract

backgroundPoint-of-care HIV viral load testing may enhance patient care and improve HIV health services. We aimed to evaluate the feasibility and acceptability of implementing such testing in a high-volume community sexual health clinic in the United States.

methodsWe conducted a cross-sectional, mixed-methods study. Remnant venipuncture specimens from clients undergoing HIV and other sexual health screenings were analyzed using the Xpert

resultsWe analyzed 113 samples from 111 clients. The Xpert assay showed excellent agreement with COBAS, with no clinically significant difference in viral load measurements. Clinical staff found Xpert testing acceptable, based on its ability to provide rapid, accurate test results and potential for bridging patient care gaps. Respondents noted that this testing would be particularly beneficial for individuals in whom barriers to care engagement may complicate follow-up. Challenges in implementation included machine errors as well as concerns related to staff workload, testing logistics, and the need for comprehensive equipment training.

conclusionsThis study represents the first effort in the United States to describe the feasibility of HIV viral load point-of-care testing in routine care. While the Xpert demonstrated comparable results to standard-of-care testing and staff found it acceptable, further work is needed to develop the workflow and implementation strategies that would enable real-time use and improved patient care. CLINICAL TRIAL: Not applicable.

Indexed as

HIV-1HIV InfectionsPoint-of-Care TestingViral LoadAdultCross-Sectional StudiesFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsPoint-of-Care SystemsSan FranciscoYoung AdultAcute HIV infectionAntiretroviral therapyHIVPoint-of-care testingViral load

Identifiers

PMID39762731
PMCPMC11702105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.