Evidence map›Paper›PMID 39762707›Full record

ArticleBreast cancer research and treatment2025

Assessment of the functional and health-related needs of patients with metastatic breast cancer prior to initiation of cancer treatment.

Sasha E Knowlton, Alexis C Wardell, Carley Bailey, Brianna Connelly, Lisa A Carey, William A Wood, Hyman Muss, Emily M Ray

Abstract read
In one paragraph

Article in Breast cancer research and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sasha E KnowltonUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA. sasha_knowlton@med.unc.edu.
Alexis C WardellUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Carley BaileyUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Brianna ConnellyUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Lisa A CareyUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
William A WoodUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Hyman MussUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.
Emily M RayUniversity of North Carolina School of Medicine, Chapel Hill, NC, USA.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
AHRQ HHS K08 HS028862NCATS NIH HHS UL1 TR002489
6 · The paper itself

Abstract

purposeTo identify needs of metastatic breast cancer patients prior to starting a new systemic treatment.

methodsFifty patients with newly diagnosed, recurrent, or progressive metastatic breast cancer completed an electronic survey which included patient-reported outcome measures of function (PROMIS Cancer Function Brief 3D profile), quality of life (FACT-G), exercise (Godin Leisure-Time exercise questionnaire), and diet (REAP-S); demographic information; and self-reported use of or referral to specific resources at the cancer center prior to beginning a new systemic oncologic treatment.

resultsPrior to starting a new treatment for metastatic breast cancer, patients reported mild functional impairment (PROMIS Cancer Function Brief 3D profile mean score:42.1) and low quality of life (FACT-G: 50%) along with low diet quality (REAP-S mean score: 29). Fifty-two percent of patients were sedentary (Godin Leisure-Time exercise questionnaire) and major barriers to exercise were pain (38%) and fatigue (34%); however, patients expressed a high level of interest (86%) in improving their ability to tolerate cancer treatment by addressing these areas.

conclusionPatients with new or recurrent metastatic breast cancer face health-related issues including sedentary behavior, poor diet, and limitations including pain and fatigue that can be addressed in prehabilitative efforts prior to starting a new oncologic treatment.

Indexed as

Breast NeoplasmsNeeds AssessmentAdultAgedExerciseFemaleHumansMiddle AgedNeoplasm MetastasisPatient Reported Outcome MeasuresQuality of LifeSurveys and QuestionnairesFunctionMetastatic breast cancerPrehabilitationQuality of life

Identifiers

PMID39762707
PMCPMC12188612

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.