Evidence map›Paper›PMID 39762701›Full record

ArticleBulletin of experimental biology and medicine2024

Changes in Functional Activity of Platelets under the Influence of Submicron Particles Based on Mesoporous Silica and pH-Sensitive Polymers.

A N Ivanov, A O Kuznetsov, D D Loiko, Yu N Vlasicheva, E V Lengert, A V Ermakov

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

A N IvanovSaratov State Medical University named after V. I. Razumovsky, Saratov, Russia.
A O KuznetsovInstitute of Molecular Theranostics, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.
D D LoikoSaratov State Medical University named after V. I. Razumovsky, Saratov, Russia.
Yu N VlasichevaDmitry Mendeleev University of Chemical Technology of Russia, Moscow, Russia.
E V LengertSaratov State Medical University named after V. I. Razumovsky, Saratov, Russia.
A V ErmakovSaratov State Medical University named after V. I. Razumovsky, Saratov, Russia. ermakov_a_v_2@staff.sechenov.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro and in vivo effects of mesoporous silica nanoparticles (MSN) on the functional activity of platelets were studied in experiments on white rats. MSN particles, neither uncoated nor coated with calcium alginate, induced spontaneous platelet aggregation when added to platelet-rich plasma, but significantly enhanced ADP-induced platelet aggregation. Subcutaneous administration of uncoated and calcium alginate-coated MSN resulted in increased maximum size and rate of platelet aggregate formation 1 day post-injection. In contrast, cellulose-coated MSN had no significant effect on platelet function in vitro or in vivo, suggesting their potential as carriers for targeted drug delivery.

Indexed as

Blood PlateletsNanoparticlesPlatelet AggregationSilicon DioxideAlginatesAnimalsCelluloseDrug CarriersGlucuronic AcidHexuronic AcidsHydrogen-Ion ConcentrationMaleParticle SizePlatelet-Rich PlasmaPorosityRatsAlginatesCelluloseDrug CarriersGlucuronic AcidHexuronic AcidsSilicon Dioxidemesoporous silicaplatelet aggregationtargeted drug delivery

Identifiers

PMID39762701

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.