Evidence map›Paper›PMID 39762691›Full record

Observational studyGeroScience2025

Associations between physical activity, brain health, cognitive function, and circulating GPLD1 in healthy older (65-85 years) individuals.

Kara L Marlatt, Adam C Lowe, Guillermo Sanchez-Delgado, Robbie A Beyl, Matthew K Viverito, Jeffrey N Keller, Owen T Carmichael, Eric Ravussin

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kara L MarlattPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0001-7721-7900
Adam C LowePennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0002-6907-1056
Guillermo Sanchez-DelgadoPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0003-4455-2483
Robbie A BeylPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0002-8582-744X
Matthew K ViveritoPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0009-0004-7555-5374
Jeffrey N KellerPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0002-9892-7423
Owen T CarmichaelPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.ORCID 0000-0002-0576-0047
Eric RavussinPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. eric.ravussin@pbrc.edu.ORCID 0000-0003-2129-547X

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
Influence of menopause on adipose tissue accumulation and functionK01DK128227 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI MARLATT, KARA L. · 2022 to 2022
$125k
NIDDK NIH HHS K01 DK128227NIDDK NIH HHS K01DK128227NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940NIGMS NIH HHS U54GM104940Nutrition Obesity Research Center, Pennington Biomedical Research Center P30DK072476
6 · The paper itself

Abstract

Declines in physical and cognitive function are common in older adults. The circulating enzyme glycosylphosphatidylinositol (GPI)-specific phospholipase D1 (GPLD1) is elevated after exercise and has been associated with improved cognitive function when administered to aged mice. The purpose of this study was to investigate the relationship between GPLD1 and both cognitive function and brain structure/function in older adults with either high or low levels of physical activity. Healthy men and women aged 65 to 85 years with a body mass index between 20 and 35 kg/m

Indexed as

BrainCognitionExercisePhospholipase DAgedAged, 80 and overFemaleHumansMagnetic Resonance ImagingMalePhospholipase Dphospholipase D1AgingBrain structureExerciseMRI

Identifiers

PMID39762691
PMCPMC12181451

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.