ArticleAesthetic plastic surgery2025
Innovative Mechanical Processing of Adipose Tissue: A Comparative Evaluation of Microfat and Concentrated Micronized Fat for Superficial Fat Grafting.
Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Adipose-Derived Stem Cells in Ophthalmic Regenerative Medicine: From Cell Replacement to Precision Engineering.Stem cell reviews and reports · 2026Review
- The Micronizer: A Novel Sharp-Bladed Device for Fat Graft Micronization to Optimize Adipocyte Viability.Cureus · 2026Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuperficial autologous fat grafting is widely used for facial rejuvenation and regenerative treatments, yet its retention rate remains unpredictable. Enhancing the concentration of adipose-derived stem cells (ASCs) has been shown to improve graft retention. Mechanical fat processing techniques can reduce fat granules size for superficial injection as well as elevate the concentration of ASCs.
objectivesWe introduced a novel mechanical fat processing method to convert macrofat into concentrated micronized fat (CMF), which can generate small fat particles and increase the concentration of ASCs. The microstructure, cell composition, and in vivo evaluation of microfat and CMF were compared.
methodsAdipose tissue was harvested from patients undergoing liposuction. Microfat was obtained using a multiperforated cannula with multiple 1.0-mm smooth side holes, while CMF was prepared with a spinning sharp blade to create smaller particles. Cell counting, viability assays, flow cytometry, ELISA, and in vivo studies were conducted to evaluate the processed fat.
resultsBoth CMF and microfat were suitable for superficial fat grafting with 26-gauge needles. Scanning electron microscopy and whole-mounting stain showed that the CMF maintained an integral histological structure. Cell count and flow cytometry tests revealed that the number of ASCs increased significantly in the CMF group compared with the microfat group. In vivo studies demonstrated higher fat retention rates in the CMF group, accompanied by reduced fibrosis and inflammation observed.
conclusionsThe CMF method significantly improves fat graft survival. This innovative approach provides a viable option for improving the outcomes of superficial fat grafting, offering better structural preservation compared to traditional microfat methods. NO LEVEL ASSIGNED: This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.