Evidence map›Paper›PMID 39762369›Full record

ArticleScientific reports2025

Targeting mutant p53: Evaluation of novel anti-p53

Diana Spiegelberg, Le-Ann Hwang, Khian Hong Pua, Sashwini Chandra Kumar, Xin Yu Koh, Xiao Hui Koh, Ram Kumar Selvaraju, Kanaga Sabapathy, Marika Nestor, David Lane

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diana SpiegelbergDepartment of Immunology, Genetics, Pathology, Uppsala University, Uppsala, Sweden. Diana.spiegelberg@uu.se.
Le-Ann HwangDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, 168583, Singapore.
Khian Hong PuaInstitute of Molecular and Cellular Biology, ASTAR, Singapore, 138673, Singapore.
Sashwini Chandra KumarDivisions of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, 168583, Singapore.
Xin Yu KohInstitute of Molecular and Cellular Biology, ASTAR, Singapore, 138673, Singapore.
Xiao Hui KohInstitute of Molecular and Cellular Biology, ASTAR, Singapore, 138673, Singapore.
Ram Kumar SelvarajuPreclinical PET-MRI Platform, Part of Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden.
Kanaga SabapathySchool of Biological Sciences, Nanyang Technological University, Singapore, 637551, Singapore.
Marika NestorDepartment of Immunology, Genetics, Pathology, Uppsala University, Uppsala, Sweden.
David LaneDepartment of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

About 50% of all cancers carry a mutation in p53 that impairs its tumor suppressor function. The p53 missense mutation p53

Indexed as

Antibodies, MonoclonalTumor Suppressor Protein p53AnimalsAutoradiographyCell Line, TumorFemaleHumansIodine RadioisotopesMiceMolecular ImagingMutation, MissenseNeoplasmsSingle Photon Emission Computed Tomography Computed TomographyTissue DistributionAntibodies, MonoclonalIodine RadioisotopesTumor Suppressor Protein p53Cancer diagnosticsIntracellular targetsMolecular imagingMutant p53

Identifiers

PMID39762369
PMCPMC11704002

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.