ArticleScientific reports2025
Synthesis of Schiff bases based on Chitosan, thermal stability and evaluation of antimicrobial and antitumor activities.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Review
- Chitosan-quinoxaline Schiff base hydroxyapatite composite with antimicrobial properties for bone regeneration.Scientific reports · 2026Article
- Hydrogels in head and neck cancer: Innovations and translational advances in research and therapy.Biomaterials · 2026Review
- Synthesis and biological study of thiopheneyl/piperazinl-α-aminophosphonate-chitosan conjugates as biologically active carriers for controlled delivery of curcumin.Scientific reports · 2026Article
- Chitosan Derivatives: Challenges and Opportunities in the Green and Sustainable Transition Era.Molecules (Basel, Switzerland) · 2026Review
- Eco-Friendly Dye Removal Using Chitosan: Characterization and Kinetic Modeling of Methylene Blue and Methyl Orange Adsorption.Polymers · 2026Article
- Comprehensive Investigation of a Novel Schiff Base: Synthesis, Anticancer Efficacy, Gene Expression Profiling, and Computational Analyses.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Sustainable α-AO@CS composite for effective humic acid elimination from water.Scientific reports · 2026Article
- Article
- Synthesis, Characterisation and Preliminary Antimicrobial Evaluation of Chitosan-4-Anisaldehyde Conjugates.Polymers · 2025Article
- Chitosan Derivatives Associated with Ceftazidime: Study of Controlled Release and Antibacterial Activity.ACS omega · 2025Article
- Influence of Er- and Al-Doped ZnO on Mixed-Matrix Membranes of Chitosan Derivatives in Bioelectrochemical Systems.Molecules (Basel, Switzerland) · 2025Article
- Influence of pyridyl nitrogen's position and hydrogen bonding interactions on antibacterial activities investigated by in vitro and in silico.Scientific reports · 2025Article
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Authors and funding
8 authors.
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Abstract
A Schiff base of Chitosan was prepared by condensing of the Chitosan (CS) with six aromatic aldehydes and confirmed by FT-IR, NMR, XRD, TGA, and DSC. XRD results showed the disappeared of peaks at 2θ = 10° for CS and appeared one peaks at around 2θ of 23° for Schiff bases, while TGA was demonstrated that the thermal stability of CS has improved after the modification with the corresponding aldehyde. Also, DSC shows endothermal peak of CS at 100 °C due to the loss of water and second thermal event related to the decomposition of amine units with an exothermic peak at 295 °C, while Schiff bases shows endothermal peak around 70-95 °C which is related to the loss of water for all samples and the second exothermic peak around 260-280 °C is related to the decomposition of the amine group in the polymer units. The antimicrobial activities of Schiff bases were tested against + ve/ - ve Gram bacteria, and fungi, while antitumor activities were evaluated against cell lines, MCF-7, HCT-116, and HepG-2. The result shows that Schiff bases exhibited higher antimicrobial activity than Amoxycillin and Tetracycline, while Schiff bases indicated the absence of cytotoxic activity when compared to the Colchicine.
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