Evidence map›Paper›PMID 39762204›Full record

ReviewExpert reviews in molecular medicine2025

Adenosinergic Signalling in Cervical Cancer Microenvironment.

Isabele Cristiana Iser, Ana Paula Santin Bertoni, Liziane Raquel Beckenkamp, Marcia Edilaine Lopes Consolaro, Silvya Stuchi Maria-Engler, Marcia Rosângela Wink

Abstract readReview
In one paragraph

Review in Expert reviews in molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabele Cristiana IserDepartment of Basics Health Sciences and Laboratory of Cell Biology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.ORCID 0000-0002-4353-4577
Ana Paula Santin BertoniDepartment of Basics Health Sciences and Laboratory of Cell Biology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Liziane Raquel BeckenkampDepartment of Basics Health Sciences and Laboratory of Cell Biology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.
Marcia Edilaine Lopes ConsolaroDepartment of Clinical Analysis and Biomedicine, Division of Clinical Cytology, State University of Maringá, Maringá, PR, Brazil.
Silvya Stuchi Maria-EnglerDepartment of Clinical Chemistry and Toxicology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil.
Marcia Rosângela WinkDepartment of Basics Health Sciences and Laboratory of Cell Biology, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.ORCID 0000-0001-5987-3509

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 158819Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 21/2551-0001947-6
6 · The paper itself

Abstract

Despite the emergence of the first human papillomavirus vaccine, the incidence of cervical cancer is still responsible for more than 350,000 deaths yearly. Over the past decade, ecto-5'-nucleotidase (CD73/5'-NT) and extracellular adenosine (ADO) signalling has been the subject of many investigations to target cancer progression. In general, the adenosinergic axis has been linked to tumourigenic effects. However, CD73 can play contradictory effects, probably dependent on the tumour type, tumour microenvironment and tumour stage, thus being in some circumstances, inversely related to tumour progression. We herein reviewed the pathophysiological function of CD73 in cervical cancer and performed

Indexed as

5'-NucleotidaseAdenosineSignal TransductionTumor MicroenvironmentUterine Cervical NeoplasmsAnimalsFemaleGPI-Linked ProteinsHumans5'-NucleotidaseAdenosineGPI-Linked ProteinsNT5E protein, humanadenosineadenosine kinaseCD73cervical cancermethylationNT5E

Identifiers

PMID39762204
PMCPMC11707834

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.