ReviewJournal of advanced research2025
Regulation of important natural products biosynthesis by WRKY transcription factors in plants.
Review in Journal of advanced research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The AcWRKY40-AcICS1 Module Regulates Kiwifruit Resistance to Pseudomonas syringae pv. actinidiae via Salicylic Acid Synthesis.Plant, cell & environment · 2026Article
- Integrated Transcriptomic and Metabolomic Analyses Reveal the Regulatory Drivers of Anthocyanin-Mediated Leaf Color Variation inInternational journal of molecular sciences · 2026Article
- Article
- Functional diversification of WRINKLED3 integrates fatty acid metabolism with insecticidal acylsugar production in Solanaceae species.Nature communications · 2026Article
- Transcriptome-based identification of the WRKY gene family in Polygala tenuifolia Willd. and their response to cold stress.BMC plant biology · 2026Article
- 2-Hydroxy-4-Methoxybenzaldehyde (2H4MB): Integrating Cell Culture, Metabolic Engineering, and Intelligent Genome Editing.International journal of molecular sciences · 2026Review
- Melatonin-inducedFrontiers in plant science · 2026Article
- Plant resistance: scientific basis and latest research progress.Frontiers in plant science · 2026Review
- Jasmonates mediate increased levels of ginsenosides in Panax Quinquefolius cambial meristematic cell cultures.BMC plant biology · 2025Article
- Analysis of Non-Polar Low-Molecular Metabolites in Citron (International journal of molecular sciences · 2025Article
- Molecular mechanisms of high levels of L-ascorbic acid accumulation in chestnut rose fruits.Plant communications · 2025Article
- Ecotype-specific phenolic acid accumulation and root softness in Salvia miltiorrhiza are driven by environmental and genetic factors.Plant biotechnology journal · 2025Article
- The Mining of Candidate Genes Involved in the Camphor Biosynthesis Pathway ofPlants (Basel, Switzerland) · 2025Article
- Identification, characterization, and expression analysis of WRKY transcription factors inFrontiers in plant science · 2025Article
- Advances in WRKY regulation of immune responses in medicinal plants.Frontiers in plant science · 2025Review
- WRKY transcription factors participate in abiotic stress responses mediated by sugar metabolism.Frontiers in plant science · 2025Review
- Comprehensive characterization of the WRKY gene family and their potential roles in regulation phenylphenalenone biosynthesis inFrontiers in plant science · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants produce abundant natural products, among which are species-specific and diversified secondary metabolites that are essential for growth and development, as well as adaptation to adversity and ecology. Moreover, these secondary metabolites are extensively utilized in pharmaceuticals, fragrances, industrial materials, and more. WRKY transcription factors (TFs), as a family of TFs unique to plants, have significant functions in many plant life activities. Especially in recent years, their role in the field of secondary metabolite biosynthesis regulation has received much attention. However, very little comprehensive summarization has been done to review their research progress. AIM OF REVIEW: The purpose of this work is not only to provide valuable insights into the regulation of WRKY TFs over metabolic pathways through compiling the WRKY TFs involved in these processes, but also to offer research directions for WRKY TFs by summarizing the regulatory modes of WRKY TFs in the biosynthesis of secondary metabolites, thereby increasing the yield of valuable natural products in the future. KEY SCIENTIFIC CONCEPTS OF REVIEW: Secondary metabolites can be categorized into three major classes-terpenoids, phenolic compounds, and nitrogen-containing compounds-based on their structural characteristics and biosynthetic pathways, and further subdivided into numerous subclasses. We review in detail the research progressregardingthe regulatory roles of WRKY TFs in plant secondary metabolitebiosynthesis and summarize more than 40 major related species. Additionally, we have presented the concepts of action modes of WRKY TFs involved in metabolic pathways, including direct regulation, indirect regulation, co-regulation, and self-regulation. It is helpful for others to investigate the molecular mechanisms of TF-mediated regulation. Furthermore, regarding future research prospects, we believe that research in this area lays the foundation for increasing the yield of important plant-derived natural products by molecular breeding, generating significant economic and social benefits.
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Registered trials
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