Evidence map›Paper›PMID 39761308›Full record

ArticleACS infectious diseases2025

Group B Streptococcal Membrane Vesicles Induce Proinflammatory Cytokine Production and Are Sensed in an NLRP3 Inflammasome-Dependent Mechanism in a Human Macrophage-like Cell Line.

Cole R McCutcheon, Jennifer A Gaddy, David M Aronoff, Shannon D Manning, Margaret G Petroff

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Comparison of cytokine responses to group BInfection and immunity · 2025
    Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Cole R McCutcheonDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0001-7757-0384
Jennifer A GaddyDepartment of Medicine, Division of Infectious Disease, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.ORCID 0000-0002-2192-4224
David M AronoffDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Shannon D ManningDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan 48824, United States.
Margaret G PetroffDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, Michigan 48824, United States.

Funding

Determining the contribution of zinc deficiency to perinatal Group B Streptococcus infectionsR01HD090061 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M, GADDY, JENNIFER A · 2017 to 2021
$2.5M
Reproductive and Developmental Sciences Training Program - T32T32HD087166 · NICHD · MICHIGAN STATE UNIVERSITY · PI Ronald L Chandler, Keith E Latham · 2016 to 2026
$2.5M
The Role of macrophages in chorioamnionitis and group B streptococcal infectionsR01AI134036 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ARONOFF, DAVID M · 2017 to 2021
$2.4M
Maternal Central Immune Tolerance in ReproductionR01HD100832 · NICHD · MICHIGAN STATE UNIVERSITY · PI PETROFF, MARGARET G · 2020 to 2024
$2.0M
Bacterial membrane vesicles as modulators of adverse pregnancy outcomesR21AI154192 · NIAID · MICHIGAN STATE UNIVERSITY · PI MANNING, SHANNON D., PETROFF, MARGARET G · 2020 to 2021
$415k
BLRD VA I01 BX005352NIAID NIH HHS R01 AI134036NIAID NIH HHS R21 AI154192NICHD NIH HHS R01 HD090061NICHD NIH HHS R01 HD100832NICHD NIH HHS T32 HD087166
6 · The paper itself

Abstract

Group B

Indexed as

CytokinesInflammasomesMacrophagesNLR Family, Pyrin Domain-Containing 3 ProteinStreptococcus agalactiaeCell LineHumansStreptococcal InfectionsTHP-1 CellsCytokinesInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humancytokinesinflammasomeinflammationmacrophageStreptococcusvesicles

Identifiers

PMID39761308
PMCPMC11833861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.