Evidence map›Paper›PMID 39760986›Full record

ArticleApplied biochemistry and biotechnology2025

Quercetin Derivatives from Bidens pilosa Suppressed Cell Proliferation via Inhibition of RSK2 Kinase and Aldose Reductase Enzymes: UPLC-MS/MS, GC-MS, In Vitro, and Computational Studies.

Doaa S Ali, Alaadin E El-Haddad, Hussein S Mohamed, Ashraf A El-Bassuony, Momtaz M Hegab, Gehad AbdElgayed, Hossam Ebaid, Shimaa A Ahmed, Emadeldin M Kamel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied biochemistry and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Exploring dynamic changes in metabolic profiles ofFrontiers in plant science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Doaa S AliChemistry of Medicinal and Aromatic Plants Department, Research Institute of Medicinal and Aromatic Plants, Beni-Suef University, Beni-Suef, 62514, Egypt.
Alaadin E El-HaddadPharmacognosy Department, Faculty of Pharmacy, October 6 University, Giza, Egypt.
Hussein S MohamedChemistry of Medicinal and Aromatic Plants Department, Research Institute of Medicinal and Aromatic Plants, Beni-Suef University, Beni-Suef, 62514, Egypt. Hussein.shaban@rimp.bsu.edu.eg.ORCID http://orcid.org/0000-0001-8305-0561
Ashraf A El-BassuonyChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
Momtaz M HegabBotany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Gehad AbdElgayedIntegrated Molecular Plant Physiology Research, Department of Biology, University of Antwerp, 2020, Antwerp, Belgium.
Hossam EbaidDepartment of Zoology, College of Science, King Saud University, P.O. Bo2455, 11451, Riyadh, Saudi Arabia.
Shimaa A AhmedChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.
Emadeldin M KamelChemistry Department, Faculty of Science, Beni-Suef University, Beni-Suef, 62514, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditionally, Bidens pilosa L. is an edible herb utilized for various ailments. The study accomplished a complete analysis of B. pilosa extract including UPLC/T-TOF-MS/MS, GC-MS, and in vitro antiproliferative activity, in addition to molecular docking on kinase and aldose reductase enzymes. From GC-MS analysis, the percentage of identified unsaturated fatty acids (FAs) (11.38%) was greater than saturated FAs (8.69%), while the sterols percent (39.92%) was higher than the hydrocarbons percent (6.6%). Oleic and palmitic acids are the major FAs (9.48% and 6.14%, respectively). Phytochemical profile uncovered the presence of quercetin, kaempferol, myricetin, and isorhamnetin aglycones and/or glycoside derivatives alongside apigenin, acacetin, and luteolin derivatives. B. pilosa extract suppressed cell proliferation in a concentration-dependent manner against SNB-19 and SK-MEL-5 cell lines (IC

Indexed as

Aldehyde ReductaseBidensCell ProliferationProtein Kinase InhibitorsQuercetinRibosomal Protein S6 Kinases, 90-kDaCell Line, TumorGas Chromatography-Mass SpectrometryHumansLiquid Chromatography-Mass SpectrometryMolecular Docking SimulationTandem Mass SpectrometryAldehyde ReductaseProtein Kinase InhibitorsQuercetinRibosomal Protein S6 Kinases, 90-kDaAntiproliferativeBidens pilosaDockingFlavonoidsGC–MSLC–MS/MS

Identifiers

PMID39760986
PMCPMC11985646

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.