Evidence map›Paper›PMID 39760981›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2025

Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial.

William Turner, Linda Boonstra, Cynthia Maxwell, Kristy Downey, Mrinalini Balki

Registry-linked trialAbstract readEquivalence TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04902729 (Oxytocin Vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04902729 nacompletednot on this map

Oxytocin Vs Carbetocin at Cesarean Delivery in Women With Morbid Obesity: Double-blind, Randomised Control, Non-inferiority Trial

TypeinterventionalSponsorSamuel Lunenfeld Research Institute, Mount Sinai HospitalRan2021 to 2022Enrolled48ConditionsPost Partum HemorrhageArmsCarbetocin, Oxytocin
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Designing and reporting a noninferiority trial: points to ponder.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
  3. In reply: Designing and reporting a noninferiority trial: points to ponder.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William TurnerDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, Mount Sinai Toronto, ON, Canada. wturner1@nhs.net.ORCID 0000-0001-5641-1202
Linda BoonstraDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, Mount Sinai Toronto, ON, Canada.
Cynthia MaxwellDepartment of Anesthesiology & Pain Medicine, University of Toronto, Toronto, ON, Canada.
Kristy DowneyDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, Mount Sinai Toronto, ON, Canada.
Mrinalini BalkiDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, Mount Sinai Toronto, ON, Canada.

Funding

Research Support, Non-US Gov’t
6 · The paper itself

Abstract

purposeClass III obesity (body mass index [BMI] ≥ 40 kg·m

methodsWe conducted a randomized, double-blind, noninferiority study in nonlabouring, term parturients with BMI ≥ 40 kg·m

resultsForty-seven participants were included in the analysis. Median tone at 3 min was similar for oxytocin (8; 95% confidence interval [CI], 7 to 8) and carbetocin (8; 95% CI, 8 to 9) (P = 0.06), with no difference at 5 and 10 min. Blood loss, side effects, and the need for additional uterotonics were not significantly different between the study groups.

conclusionWe conclude that carbetocin is noninferior to oxytocin at elective Cesarean delivery in parturients with class III obesity, with the advantage of single bolus dosing without infusion. STUDY REGISTRATION: ClinicalTrials.gov ( NCT04902729 ); first submitted 21 May 2021.

Indexed as

Cesarean SectionObesity, MorbidOxytocicsOxytocinAdultBody Mass IndexDouble-Blind MethodElective Surgical ProceduresFemaleHumansInfusions, IntravenousPostpartum HemorrhagePregnancyYoung AdultcarbetocinOxytocicsOxytocincarbetocinCesarean deliveryobesityoxytocinpostpartum hemorrhage

Identifiers

PMID39760981

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.