Trial reportInternational journal of implant dentistry2025
Effect of nanogold incorporation into polymethyl methacrylate denture bases on microbial activity in implant-retained mandibular overdentures.
Trial report in International journal of implant dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nanoparticle-Based Drug Delivery Systems: Current Advances and Future Directions.Current drug targets · 2026Review
- Nano-particle coated or impregnated acrylic resins in dental applications: A systematic review of in Vivo Evidence on mechanical properties, biocompatibility and clinical performance.Journal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn this randomized clinical trial, we examined the incorporation of nanogold particles into polymethyl methacrylate denture bases and compared these modified bases with conventional ones in mandibular implant-retained overdentures, focusing on microbiological growth and adhesion characteristics.
methodsIn this study, twenty-two male patients who were completely edentulous participated in a rehabilitation program involving mandibular overdentures retained by two dental implants placed in the canine area. The subjects were categorized into two equal groups, each comprising eleven patients. Group I received mandibular overdentures fabricated from conventional acrylic denture bases, whereas Group II received mandibular overdentures with bases that had undergone nanogold treatment. Microbial growth and colonization were evaluated around the implant's necks and the fitting surface of each patient's mandibular dentures. Three types of bacteria were studied: Candida albicans, Escherichia coli, and Streptococcus mutans. The mean difference in the counts of bacteria before the denture was inserted and after two, four, and six months has been calculated and analyzed statistically.
resultsRegarding colony count (log 10 CFUs/mmL), there was a significant difference between the research groups. Group II had significantly lower values measured at 2, 4, and 6 months for Candida albicans, Escherichia coli, and Streptococcus mutans, respectively, than group I.
conclusionThe addition of gold nanoparticles to PMMA denture bases was of greater benefit in inhibiting microbial growth than conventional acrylic resin bases.
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