Evidence map›Paper›PMID 39760954›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Optimization of Eco-Friendly Extraction of Bioactive Compounds from Mentha spicata L. Using Ultrasound-Assisted Extraction Combined with Choline Chloride-Based Deep Eutectic Solvents.

Aleksandra Szydłowska-Czerniak, Aleksandra Moździerz, Agnieszka Kowaluk, Michał Strzelec, Patrycja Topka, Tomasz Sawicki, Małgorzata Tańska

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aleksandra Szydłowska-CzerniakDepartment of Analytical Chemistry and Applied Spectroscopy, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Toruń, 87-100, Poland. olasz@umk.pl.
Aleksandra MoździerzDepartment of Analytical Chemistry and Applied Spectroscopy, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Toruń, 87-100, Poland.
Agnieszka KowalukDepartment of Physical and Environmental Chemistry, Laboratory of Electrochemical and Inorganic Analyzes, Central Office of Measures, Warszawa, 00-139, Poland.
Michał StrzelecDepartment of Physical and Environmental Chemistry, Laboratory of Electrochemical and Inorganic Analyzes, Central Office of Measures, Warszawa, 00-139, Poland.
Patrycja TopkaDepartment of Food Plant Chemistry and Processing, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, 10-718, Poland.
Tomasz SawickiDepartment of Human Nutrition, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, 10-718, Poland.
Małgorzata TańskaDepartment of Food Plant Chemistry and Processing, Faculty of Food Sciences, University of Warmia and Mazury in Olsztyn, Olsztyn, 10-718, Poland. m.tanska@uwm.edu.pl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Three choline chloride (ChCl)-based deep eutectic solvents (DESs) as a new type of green solvents were used for the ultrasound-assisted extraction (UAE) of bioactive compounds from Mentha spicata L. DES containing ChCl and malonic acid (MalA) was selected as the most promising, providing a more effective extraction of antioxidants from spearmint. Response surface methodology (RSM) and a Box-Behnken design (BBD) with three variables, ChCl:MalA molar ratio, water content (WC) in DES, and extraction time (t), were implemented for optimizing the extraction conditions. The optimal conditions were calculated to maximize the antioxidant capacity (AC) determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and cupric reducing antioxidant capacity (CUPRAC) assays, total phenolic acids (TPAc), total flavonoid aglycones (TFAgly), and total flavonoid glycosides (TFGly). The phenolic profiles in the obtained extracts were analyzed using ultra-performance liquid chromatography (UPLC), revealing that rosmarinic acid, ellagic acid, rutin, kaempferol, and kaempferol-3-O-rutinoside were predominant in the DES extracts.

Indexed as

AntioxidantsCholineDeep Eutectic SolventsMentha spicataPlant ExtractsChromatography, High Pressure LiquidDepsidesPhenolsUltrasonicsAntioxidantsCholineDeep Eutectic SolventsDepsidesPhenolsPlant ExtractsAntioxidant capacityExtractionGreen solventsPhenolic compoundsResponse surface methodologySpearmintUltra-performance liquid chromatography

Identifiers

PMID39760954

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.