Evidence map›Paper›PMID 39760942›Full record

ArticleBulletin of experimental biology and medicine2024

Features of Metabolism and Its Regulation in the Dynamics of Experimental Models of Metabolic Disorders.

A V Shestopalov, E V Krolenko, A A Nedorubov, O V Borisenko, K E Popruga, V V Makarov, S M Yudin, A M Gaponov, S A Rumyantsev

Abstract read
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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A V ShestopalovDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation, Moscow, Russia.
E V KrolenkoPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia. krolenko_ev@rsmu.ru.
A A NedorubovCenter for Digital and Translational Biomedicine, Center for Molecular Health LLC, Moscow, Russia.
O V BorisenkoPirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
K E PoprugaCentre for Strategic Planning and Management of Biomedical Health Risks, Federal Medical-Biological Agency of Russia, Moscow, Russia.
V V MakarovNational Medical Research Center of Endocrinology, Ministry of Health of the Russian Federation, Moscow, Russia.
S M YudinCentre for Strategic Planning and Management of Biomedical Health Risks, Federal Medical-Biological Agency of Russia, Moscow, Russia.
A M GaponovCenter for Digital and Translational Biomedicine, Center for Molecular Health LLC, Moscow, Russia.
S A RumyantsevCenter for Digital and Translational Biomedicine, Center for Molecular Health LLC, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor β1 (TGF-β1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-β1 were detected. In NOD mice, reduced number of insulin-positive β cells, hyperinsulinemia, and a decrease in adiponectin, TGF-β1, leptin, and myostatin concentrations were detected.

Indexed as

Metabolic DiseasesObesityAdiponectinAdipose TissueAnimalsCholesterolDisease Models, AnimalHyperglycemiaHyperinsulinismLeptinLipid MetabolismLiverMaleMiceMice, Inbred C57BLMyostatinAdiponectinCholesterolLeptinMyostatinTransforming Growth Factor beta1TriglyceridesC57BL/6db/dbdiabetes mellitusNODobesity

Identifiers

PMID39760942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.