Evidence map›Paper›PMID 39760941›Full record

ArticleBulletin of experimental biology and medicine2024

Stratification of Experimental LPS-Induced Systemic Inflammatory Response by Expression Level of Hif1a and NFkb Genes.

A M Kosyreva, D Sh Dzhalilova, E A Miroshnichenko, O V Makarova

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

A M KosyrevaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. kosyreva.a@list.ru.
D Sh DzhalilovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
E A MiroshnichenkoAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
O V MakarovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It was previously found that the severity of LPS-induced systemic inflammatory response (SIRS) in rats is determined by resistance to hypoxia and the level of Hif1a expression. Individual differences in the level of Hif1a and NFkb expression in the liver were studied in relation to the severity of inflammatory and immune reactions in LPS-induced SIRS in rats without previous placement in a ventilated decompression chamber. During the early periods after SIRS modeling, rats with high expression of the Hif1a and NFkb genes associated with increased expression of pro- and anti-inflammatory cytokines are identified. These animals have a high blood level of corticosterone, low number of neutrophils in the interalveolar septa, and a predominance of T cells over B cells in the peripheral blood. The obtained data can be used to develop new approaches to the individual prediction of the severity of sepsis and SIRS in intensive care units, which will increase the effectiveness of therapy and reduce mortality rate.

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitNF-kappa BSystemic Inflammatory Response SyndromeAnimalsCorticosteroneCytokinesLipopolysaccharidesLiverMaleNeutrophilsRatsRats, WistarCorticosteroneCytokinesHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitLipopolysaccharidesNF-kappa BendotypesHif1a and NFkb genespredictorssepsissystemic inflammatory response (SIRS)

Identifiers

PMID39760941

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.