Evidence map›Paper›PMID 39760919›Full record

ArticleNatural products and bioprospecting2025

Discovery of a parallel family of euglenatide analogs in Euglena gracilis.

Ahmed H Elbanna, Xinhui Kou, Dilip V Prajapati, Surasree Rakshit, Rebecca A Butcher

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ahmed H ElbannaDepartment of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Xinhui Kou *Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Dilip V Prajapati *Department of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Surasree RakshitDepartment of Chemistry, University of Florida, Gainesville, FL, 32611, USA.
Rebecca A ButcherDepartment of Chemistry, University of Florida, Gainesville, FL, 32611, USA. butcher@chem.ufl.edu.ORCID http://orcid.org/0000-0002-0925-4459

Funding

Small-molecule signals controlling nematode developmentR35GM144076 · NIGMS · UNIVERSITY OF FLORIDA · PI Rebecca A Butcher · 2022 to 2026
$2.1M
Acquisition of timsTOF Pro for Complex Lipidomic AnalysesS10OD030250 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2022 to 2022
$658k
NMR console upgrade for structural biology and metabolomicsS10OD028753 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2020 to 2020
$600k
NIGMS NIH HHS R35 GM144076NIH HHS S10 OD028753NIH HHS S10 OD030250
6 · The paper itself

Abstract

The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracilis. These compounds have antiproliferative activity against fungal pathogens and mammalian cancer cell lines. Analysis of E. gracilis extracts revealed that the algae produce not only the euglenatides, but also a corresponding family of analogs that have the same molecular weights as the euglenatides, but are lacking the characteristic triene chromophore. In comparison to the euglenatides, the activity of these analogs is greatly reduced in a mammalian cytotoxicity assay, indicating that the triene is critical to the biological activity of the euglenatides.

Indexed as

Euglena gracilisEuglenatideNatural productsNonribosomal peptidePolyketide

Identifiers

PMID39760919
PMCPMC11703798

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.