Evidence map›Paper›PMID 39760917›Full record

ReviewCurrent nutrition reports2025

Omega-3 Polyunsaturated Fatty Acids in Chronic Obstructive Pulmonary Disease Patients with COVID-19: A Review.

Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Kuan-Pin Su, Jane Pei-Chen Chang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current nutrition reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Halliru ZailaniMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Senthil Kumaran SatyanarayananMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Wei-Chih LiaoDivision of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan. weichih.liao@gmail.com.
Kuan-Pin SuMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan.
Jane Pei-Chen ChangMind-Body Interface Research Center (MBI-Lab), China Medical University Hospital, Taichung, Taiwan. peko80@gmail.com.

Funding

An-Nan Hospital, China Medical University, Tainan, Taiwan ANHRF 109-31, 109-40, 110-13, 110-26, 110-44, 110-45, 111-27, 111-28, 111-47, 111-48, and 111-52China Medical University Hospital DMR-106-101, 106-227, 109-102, 109-244, 110-124, 111-245, 112-097, 112-086, 112-109 and DMR-HHC-109-11, HHC-109-12, HHC-110-10, and HHC-111-8China Medical University, Taiwan CMU 110- AWARD-02, 110-N-17, 1110-SR-73Higher Education Sprout Project by the Ministry of Education, Taiwan CMRC-CMA-2Ministry of Science and Technology, Taiwan MOST 109-2320-B-038-057- MY3, 110-2321-B-006-004, 110-2811-B-039-507, 110-2320-B-039-048-MY2,110-2320-B-039- 047-MY3, 110-2813-C-039-327-B, 110-2314-B-039-029-MY3, 111-2321-B-006-008, and NSTC 111-2314-B-039-041-MY3
6 · The paper itself

Abstract

purpose of the reviewMounting evidence indicates that individuals with chronic obstructive pulmonary disease (COPD) face a heightened risk of severe outcomes upon contracting coronavirus disease 2019 (COVID-19). Current medications for COVID-19 often carry side effects, necessitating alternative therapies with improved tolerance. This review explores the biological mechanisms rendering COPD patients more susceptible to severe COVID-19 and investigates the potential of omega-3 polyunsaturated fatty acids (n-3 PUFAs) in mitigating the severity of COVID-19 in COPD patients. RECENT

findingsCurrent evidence indicates that COPD patients are at an increased risk of severe COVID-19 due to factors including compromised pulmonary function, dysregulated inflammation, weakened immune response, increased oxidative stress, elevated expression of angiotensin-converting enzyme (ACE2) receptors in the lungs, and genetic predispositions. Remarkably, n-3 PUFAs exhibit the potential in ameliorating the clinical outcomes of COPD patients with COVID-19 by modulating inflammation, reinforcing the body's antioxidant defenses, reducing viral entry and replication, and enhancing immunity. N-3 PUFAs hold potential for improving COVID-19 outcomes in patients with COPD. However, there has been limited investigation into the therapeutic effects of n-3 PUFAs in enhancing clinical outcomes for COPD patients. Rigorous clinical studies are essential to evaluate the impact of n-3 PUFAs on COPD patients with concurrent COVID-19 infection.

Indexed as

COVID-19Fatty Acids, Omega-3Pulmonary Disease, Chronic ObstructiveHumansInflammationLungOxidative StressSARS-CoV-2Fatty Acids, Omega-3AntioxidantsCOPDCOVID-19CytokinesOmega-3 polyunsaturated fatty acidsSpecialised pro-resolving mediators

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.