Evidence map›Paper›PMID 39760810›Full record

ArticleMetabolic brain disease2025

Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB.

Chandra Prakash, Jyoti Tyagi, Kumari Vandana Singh, Gautam Kumar, Deepak Sharma

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandra PrakashNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Jyoti TyagiNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Kumari Vandana SinghDepartment of Laboratory Medicine, Jaiprakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, 110029, India.
Gautam KumarSchool of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Deepak SharmaNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India. sharmadeepakjnu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aluminium is a common metallic toxicant that easily penetrates the brain and exerts severe pathological effects e.g., oxidative stress, inflammation and neurodegeneration. Eugenol is a natural phenolic compound possessing numerous therapeutic properties including antioxidant, anti-inflammatory and neuroprotective. The compound has also been reported to interfere with important transcription factors like STAT3 and NF-кB. Thus, the present study intended to explore the therapeutic potential of eugenol in aluminium neurotoxicity. Rats were administered AlCl

Indexed as

Aluminum ChlorideEugenolNeuroprotective AgentsNeurotoxicity SyndromesNF-kappa BOxidative StressSTAT3 Transcription FactorAcetylcholinesteraseAluminumAluminum CompoundsAnimalsAntioxidantsBrainGlutathioneHippocampusLipid PeroxidationAcetylcholinesteraseAluminumAluminum ChlorideAluminum CompoundsAntioxidantsEugenolGlutathioneNeuroprotective AgentsNF-kappa BStat3 protein, ratSTAT3 Transcription FactorAluminiumAstrogliosisEugenolNeurotoxicityNF-кBSTAT3

Identifiers

PMID39760810

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.