Evidence map›Paper›PMID 39760535›Full record

ReviewExpert review of gastroenterology & hepatology2025

Modulating the microbiome in chronic liver diseases - current evidence on the role of fecal microbiota transplantation.

Srishti Saha, Bernd Schnabl

Abstract readReview
In one paragraph

Review in Expert review of gastroenterology & hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Srishti SahaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California San Diego, San Diego, CA, USA.
Bernd SchnablDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of California San Diego, San Diego, CA, USA.

Funding

San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
The Role of the Intestinal Mycobiome in Alcoholic Liver DiseaseR01AA024726 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2018 to 2026
$3.9M
Microbiome and Intestinal Innate Immune Response in Alcoholic Liver DiseaseR37AA020703 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2021 to 2026
$2.5M
Fecal microbiota transplantation for auto-brewery syndromeR21AA031410 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HOHMANN, ELIZABETH L., SCHNABL, BERND G. · 2024 to 2025
$445k
BLRD VA I01 BX004594NIAAA NIH HHS R01 AA024726NIAAA NIH HHS R21 AA031410NIAAA NIH HHS R37 AA020703NIDDK NIH HHS P30 DK120515
6 · The paper itself

Abstract

introductionThe gut microbiota has a complex relationship with the human host and is key to maintaining health. Disruption of the healthy diverse gut microbial milieu plays an important role in the pathogenesis of several diseases including AREAS COVERED: In this narrative review, we explore the role of gut microbiota in liver diseases, focusing on key changes in the microbial composition and function. We summarize current evidence on the role of FMT, identifying gaps in current research and outlining future directions for investigation. We comprehensively searched PubMed through 15 October 2024 to identify relevant studies. EXPERT OPINION: While data from available studies shows promise, more research is necessary before we can use FMT for liver diseases. Key areas that require further study are - determining the optimal FMT regimen for each disease, establishing efficacy and safety with larger clinical trials, ensuring safe and equitable access to the FMT product and mechanistic insights into the reasons for success or failure of FMT.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeLiver DiseasesChronic DiseaseClostridium InfectionsHumansTreatment OutcomeAlcohol-related liver diseasecirrhosishepatitis BMASLDmicrobial therapeuticsmicrobiotaNAFLDprimary sclerosing cholangitis

Identifiers

PMID39760535
PMCPMC11882407

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.