ArticlePediatric pulmonology2025
The Interplay Between Respiratory Syncytial Virus and Asthma Inception: Insights Gained From the COVID-19 Pandemic.
Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Respiratory morbidity at age 4 across COVID-19 and pre-pandemic birth cohorts: the role of atopic risk.European journal of pediatrics · 2026Article
- Asthma-related Pediatric Healthcare Utilization after Hospitalization for RSV and Other Viral Lower Respiratory Tract Infections.Open forum infectious diseases · 2026Article
- Impact of COVID-19 outbreak on the seasonality and incidence of type 1 diabetes mellitus: A nationwide cohort study.World journal of diabetes · 2025Article
- The impact of neonatal antibiotic exposure on the development of childhood food allergies.European journal of pediatrics · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundRespiratory syncytial virus (RSV) infection in the first year of life has been linked with an increased risk for asthma. Some propose that RSV-induced inflammation leads to lasting airway changes, while others contend that RSV bronchiolitis is a marker for underlying predisposition. Social distancing adopted during the COVID-19 pandemic has led to a dramatic reduction in RSV activity, providing an unexpected opportunity to investigate this debate.
objectiveTo compare the incidence of asthma-related healthcare-utilization (HCU) in 1-3 years of age between children born in March-June 2020 (l-RSV) and children born during the same months in the years 2014-2017 (H-RSV). STUDY DESIGN AND
methodsThis retrospective study utilized nationwide healthcare database records from Clalit-Healthcare-Services, the largest healthcare organization in Israel. The study analyzed asthma-related HCU, using multivariate logistic regression and Bayesian analyses.
results172,463 children were included in the study: 32,927 in the l-RSV group versus 139,536 in the H-RSV group. The l-RSV cohort showed insignificant changes and increased rates of asthma-related HCU between 1 and 3 years of age in some asthma surrogates, compared to the H-RSV group.
conclusionReduction in RSV exposure during the first year of life did not correlate with a decrease in asthma-related HCU. This may imply that RSV infection in infancy functions as an indicator of underlying predisposition rather than a direct cause of asthma.
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