Evidence map›Paper›PMID 39760464›Full record

ArticleGut microbes2025

Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation.

Chrissa Petersen, Adhini Kuppuswamy Satheesh Babu, Ceres Mattos Della Lucia, Henry A Paz, Lisard Iglesias-Carres, Ying Zhong, Thunder Jalili, J David Symons, Kartik Shankar, Andrew P Neilson and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Late-in-life treadmill training mitigates gut microbiome imbalances and cardiovascular disease risk in mice.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  3. Article
  4. Wild blueberries and cardiometabolic health: a current review of the evidence.Critical reviews in food science and nutrition · 2026
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chrissa PetersenDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Adhini Kuppuswamy Satheesh BabuDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Ceres Mattos Della LuciaDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6731-5694
Henry A PazArkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Lisard Iglesias-CarresPlants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA.
Ying ZhongArkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Thunder JaliliDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
J David SymonsDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.
Kartik ShankarDepartment of Pediatrics, Section of Nutrition, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Andrew P NeilsonPlants for Human Health Institute, Department of Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Kannapolis, NC, USA.
Umesh D WankhadeArkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Pon Velayutham Anandh BabuDepartment of Nutrition and Integrative Physiology, College of Health, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-8424-5421

Funding

Biological signatures of blueberry-derived microbial metabolites (Supplement)R01AT010247 · NCCIH · UNIVERSITY OF UTAH · PI PON VELAYUTHAM, ANANDH BABU · 2018 to 2021
$1.9M
National Institute of Food and Agriculture 2019-67017-29253NCCIH NIH HHS R01 AT010247USDA/NIFA 2019-67017-29253USDA/NIFA 2021-67034-35128
6 · The paper itself

Abstract

Evidence suggests that a healthy gut microbiome is essential for metabolizing dietary phytochemicals. However, the microbiome's role in metabolite production and the influence of gut dysbiosis on this process remain unclear. Further, studies on the relationship among gut microbes, metabolites, and biological activities of phytochemicals are limited. We addressed this knowledge gap using strawberry phytochemicals as a model. C57BL/6J mice were fed a standard diet [C]; strawberry-supplemented diet (~2 human servings) [CS]; strawberry-supplemented diet and treated with antibiotics (to deplete gut microbes) [CSA]; high-fat diet (HFD) [HF]; strawberry-supplemented HFD [HS]; and strawberry-supplemented HFD and treated with antibiotics [HSA] for 12 weeks. First, antibiotic treatment suppressed the production of selected metabolites (CSA

Indexed as

Diet, High-FatDysbiosisFragariaGastrointestinal MicrobiomeMice, Inbred C57BLPhytochemicalsAnimalsAnti-Bacterial AgentsBacteriaCoumaric AcidsHumansInflammationMaleMicePropionatesAnti-Bacterial AgentsCoumaric Acidsp-coumaric acidPhytochemicalsPropionatesDiet-derived metabolitesgut microbiomehost-microbiome interactionphytochemicalsstrawberriesvascular

Identifiers

PMID39760464
PMCPMC12931721

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.