Evidence map›Paper›PMID 39760327›Full record

ArticleJournal of pediatric gastroenterology and nutrition2025

Long-term growth and nutrition outcomes in children following intestinal transplantation.

Ahmad Miri, Angela K Iverson, Nathan Law, Junghyae Lee, Ruben E Quiros Navarrete, Emille M Reyes-Santiago, Warapan Nakayuenyongsuk, David F Mercer, Luciano M Vargas, Shaheed Merani and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmad MiriPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.ORCID 0000-0003-1398-4048
Angela K IversonDepartment of Clinical Nutrition, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Nathan LawSchool of Medicine, Creighton University, Omaha, Nebraska, USA.
Junghyae LeeDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ruben E Quiros NavarretePediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Emille M Reyes-SantiagoPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Warapan NakayuenyongsukPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
David F MercerTransplantation Surgery Department, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Luciano M VargasTransplantation Surgery Department, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Shaheed MeraniTransplantation Surgery Department, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Wendy J GrantTransplantation Surgery Department, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Alan N LangnasTransplantation Surgery Department, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Ruben E Quiros-TejeiraPediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Funding

None
6 · The paper itself

Abstract

objectiveIntestinal transplantation (ITx) has become an accepted option for children with serious complications from intestinal failure and parenteral nutrition (PN) dependence. We aimed to assess long-term growth and nutritional outcomes in these patients. We also assessed factors influencing nutritional status and ability to wean off tube feedings (TFs) after ITx.

methodsWe looked retrospectively into post-ITx growth parameters, nutrition treatment, and micronutrient status for children who survived for 5 or more years after ITx. One hundred thirty-three children between 1993 and 2014 were involved. Descriptive data and growth parameters were collected over 15 years after ITx. We also analyzed influencing factors, including the presence of permanent stoma, prolonged use of steroids, partial gastrectomy at the time of ITx, developmental delay, concurrent visceral transplant, and graft rejection episodes.

resultsThere was an increase in the height z-scores over the 15-year period post-ITx (p < 0.001). There was a downward trend in body mass index (BMI) z-scores over the 15-year post-ITx period. Isolated intestinal transplant patients showed a better height z-score compared to multivisceral transplant (p = 0.04). The height and BMI z-scores for patients on steroids were not significantly different from the z-scores for steroid-free patients (p = 0.72, 0.99, respectively). There was no significant change in height and BMI z-scores based on prednisolone dose: ≤0.2 mg/kg (p = 0.76); >0.2 mg/kg (p = 0.52). Patients were more likely to require supplemental TF up to 15 years post-ITx when they had partial gastrectomy (p < 0.001), permanent ostomy (p = 0.009), or developmental delay (p < 0.001).

conclusionsThere was improved long-term linear growth post-ITx. Developmental delay, partial gastrectomy, and a permanent ostomy are likely to delay TF wean post-ITx.

Indexed as

Child DevelopmentIntestinal FailureIntestinesNutritional StatusAdolescentBody HeightBody Mass IndexChildChild, PreschoolEnteral NutritionFemaleGrowth DisordersHumansInfantMaleParenteral Nutritiongastrectomyileostomypediatrictube feeds

Identifiers

PMID39760327
PMCPMC11874248

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.