Evidence map›Paper›PMID 39760094›Full record

ReviewFrontiers in cellular and infection microbiology2024

Persistent microbial infections and idiopathic pulmonary fibrosis - an insight into

Anthony Shadid, Haydn E Rich, Hunter DeVaughn, Aleksey Domozhirov, Marie-Françoise Doursout, Tingting Weng-Mills, Kristin L Eckel-Mahan, Harry Karmouty-Quintana, Marcos I Restrepo, Pooja Shivshankar

Abstract readReview
In one paragraph

Review in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anthony ShadidCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Haydn E RichCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Hunter DeVaughnCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Aleksey DomozhirovCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Marie-Françoise DoursoutDepartment of Anesthesiology, Critical Care and Pain Medicine, UTHealth-McGovern Medical School, Houston, TX, United States.
Tingting Weng-MillsDepartment of Biochemistry and Molecular Biology, UTHealth-McGovern Medical School, Houston, TX, United States.
Kristin L Eckel-MahanCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.
Harry Karmouty-QuintanaDepartment of Biochemistry and Molecular Biology, UTHealth-McGovern Medical School, Houston, TX, United States.
Marcos I RestrepoDivision of Pulmonary and Critical Care Medicine, Department of Medicine, South Texas Veterans Health Care System and the University of Texas Health San Antonio, San Antonio, TX, United States.
Pooja ShivshankarCenter for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for Prevention of Human Diseases, UTHealth-McGovern Medical School, Houston, TX, United States.

Funding

MURINE COMPLEMENT C5 DEFICIENCY--MOLECULAR BASISR01AI025011 · NIAID · WASHINGTON UNIVERSITY · PI WETSEL, RICK A. · 1987 to 2017
$4.6M
Sineoculis Homeobox Homolog 1 (Six1) in Pulmonary FibrosisR01HL157100 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARMOUTY-QUINTANA, HARRY · 2021 to 2025
$2.8M
Complement and Circadian Interactions in Inflammation and ImmunityR01AI158694 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MAHAN, KRISTIN ECKEL, SHIVSHANKAR, POOJA · 2021 to 2025
$1.9M
NHLBI NIH HHS R01 HL157100NIAID NIH HHS R01 AI025011NIAID NIH HHS R01 AI158694
6 · The paper itself

Abstract

Interstitial lung disease (ILD) is characterized by chronic inflammation and scarring of the lungs, of which idiopathic pulmonary fibrosis (IPF) is the most devastating pathologic form. Idiopathic pulmonary fibrosis pathogenesis leads to loss of lung function and eventual death in 50% of patients, making it the leading cause of ILD-associated mortality worldwide. Persistent and subclinical microbial infections are implicated in the acute exacerbation of chronic lung diseases. However, while epidemiological studies have highlighted pollutants, gastric aspirate, and microbial infections as major causes for the progression and exacerbation of IPF, the role of persistent microbial infections in the pathogenesis of IPF remains unclear. In this review, we have focused on the role of persistent microbial infections, including viral, bacterial, and fungal infections, and their mechanisms of action in the pathogenesis of IPF. In particular, the mechanisms and pathogenesis of the Gram-negative bacteria Non-typeable

Indexed as

Haemophilus InfectionsHaemophilus influenzaeIdiopathic Pulmonary FibrosisAnimalsHumansPersistent Infectionclinical studies in IPFidiopathic pulmonary fibrosis (IPF)interstitial lung diseases (ILD)mRNA-based therapeutics targeting intracellular pathogensnon-typeable-Haemophilus influenzae (NTHi)persistent microbial infection

Identifiers

PMID39760094
PMCPMC11695292

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.