ArticleChemical science2025
Long oligos: direct chemical synthesis of genes with up to 1728 nucleotides.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- eMALDI MS and oligonucleotide analysis.Chemical science · 2026Article
- GuanineOrganic & biomolecular chemistry · 2026Article
- Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences.Nature communications · 2026Article
- Chemically synthesized high-fidelity oligos ≤ 600 nt as building blocks to accelerate complex gene construction in synthetic biology.Synthetic biology (Oxford, England) · 2026Article
- The evolving landscape of precise DNA insertion in plants.Nature communications · 2025Review
- Coumarin-Based Photolabile Solid Support Facilitates Nonchromatographic Purification of RNA Oligonucleotides.The Journal of organic chemistry · 2025Article
- Scaling DNA synthesis with a microchip-based massively parallel synthesis system.Nature biotechnology · 2025Article
- cONcat: Computational reconstruction of concatenated fragments from long Oxford Nanopore reads.PloS one · 2025Article
- For Catching-by-Polymerization Oligo Purification: Scalable Synthesis of the Precursors to the Polymerizable Tagging Phosphoramidites.PeerJ organic chemistry · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The longest oligos that can be chemically synthesized are considered to be 200-mers. Here, we report direct synthesis of an 800-mer green fluorescent protein gene and a 1728-mer
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.