Evidence map›Paper›PMID 39759874›Full record

ArticleMolecular therapy. Nucleic acids2025

An mRNA vaccine induces antimycobacterial immunity by activating DNA damage repair and autophagy.

Dan Chen, Weili Huang, Lifang Shen, Junli Zhang, Zhifen Pan, Chen Zhang, Yuting Tang, Ziwei Zhou, Jie Tao, Geyang Luo and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Pathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Dan ChenDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Weili HuangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Lifang ShenState Key Laboratory of Genetic Engineering, Department of Genetics, School of Life Science, Fudan University, Shanghai 200438, China.
Junli ZhangState Key Laboratory of Genetic Engineering, Department of Genetics, School of Life Science, Fudan University, Shanghai 200438, China.
Zhifen PanDepartment of Respiratory Medicine, The First Hospital of Jiaxing in Zhejiang Province, Affiliated Hospital of Jiaxing University, Jiaxing 314000, China.
Chen ZhangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Yuting TangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Ziwei ZhouDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Jie TaoCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Geyang LuoCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Shifeng ZhangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Jing ZhouCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Shuqin XuState Key Laboratory of Genetic Engineering, Department of Genetics, School of Life Science, Fudan University, Shanghai 200438, China.
Meng ZhangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Yeyu LiDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.
Yi FangStemirna Therapeutics, Shanghai 201206, China.
Fanfan ZhaoStemirna Therapeutics, Shanghai 201206, China.
Lei HuangStemirna Therapeutics, Shanghai 201206, China.
Hangwen LiStemirna Therapeutics, Shanghai 201206, China.
Hua YangClinic and Research Centre of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200400, China.
Hong LvState Key Laboratory of Genetic Engineering, Department of Genetics, School of Life Science, Fudan University, Shanghai 200438, China.
Wei ShaClinic and Research Centre of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200400, China.
Bo YanCenter for Tuberculosis Research, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.
Jun LiuDepartment of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Lu ZhangDepartment of Microbiology, School of Life Sciences, Fudan University, Shanghai 200438, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective vaccines are urgently needed for the control of tuberculosis (TB). Here, we report that an mRNA TB vaccine is highly effective and exhibits both prophylactic and therapeutic activity in the zebrafish model of TB. Adult zebrafish immunized with the mRNA vaccine survived significantly longer after

Indexed as

autophagyDNA damage repairgranulomamRNA vaccineMT: Oligonucleotides: Therapies and Applicationstuberculosis

Identifiers

PMID39759874
PMCPMC11700299

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.