Evidence map›Paper›PMID 39759845›Full record

ArticleMaterials today. Bio2025

Hyaluronidase-responsive hydrogel loaded with magnetic nanoparticles combined with external magnetic stimulation for spinal cord injury repair.

Zhiyi Fan, Guofu Zhang, Wanda Zhan, Juehan Wang, Chaoyong Wang, QianYing Yue, Zhangheng Huang, Yongxiang Wang

Erratum issuedAbstract read
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. [Effect of composite graphene-protein hydrogels on neural regeneration after spinal cord injury in rats].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Zhiyi FanNorthern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Guofu ZhangNorthern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Wanda ZhanNorthern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.
Juehan WangDepartment of Orthopaedics and Traumatology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong.
Chaoyong WangNorthern Jiangsu People's Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Yangzhou, China.
QianYing YueJockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.
Zhangheng HuangFirst Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yongxiang WangNorthern Jiangsu People's Hospital, Yangzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a neurological condition that causes significant loss of sensory, motor, and autonomic functions below the level of injury. Current clinical treatment strategies often fail to meet expectations. Hyaluronidase is typically associated with tumor progression and bacterial infections. Analysis showed that hyaluronidase also persistently increased in a rat total excision model. In this study, we designed a highly biocompatible dual-responsive hydrogel. Hyaluronic acid (HA)-Gelatin (Gel) served as the base for the hydrogel, crosslinked via an amide reaction to form the hydrogel. The hydrogel was further combined with Neurotrophic growth factor (NGF) and Fe

Indexed as

HyaluronidaseHydrogelMagnetic fieldSpinal cord injury

Identifiers

PMID39759845
PMCPMC11697414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.