Evidence map›Paper›PMID 39759737›Full record

ArticleCureus2024

Immune Response to BNT162b2 mRNA COVID-19 Vaccine in a Cohort of Healthcare Workers.

Gemma Grau Gómez, Xavier Martínez Lacasa, Angeles Jaen, Judith Vidal Martínez, Emma Padilla, David Clemente, Siena Molina, Ales Chlouba, Susana González, Helena Monzón Camps

Abstract read
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In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gemma Grau GómezInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Xavier Martínez LacasaInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Angeles JaenResearch Unit, Fundació, Docència i Recerca Mútua Terrassa, Terrassa, ESP.
Judith Vidal MartínezCytometry Department, Catlab, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Emma PadillaMicrobiology Department, Catlab, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
David ClementeInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Siena MolinaInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Ales ChloubaInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Susana GonzálezOccupational Health, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.
Helena Monzón CampsInternal Medicine, Fundació Assistencial Mútua Terrassa, Terrassa, ESP.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this 13-month follow-up study, we examined a cohort of vaccinated healthcare workers without prior SARS-CoV-2 infection to assess the humoral and cellular response to the BNT162b2 mRNA COVID-19 vaccine over time. We measured median immunoglobulin G and lymphocyte subpopulation levels after the first and second doses, at five months post-second dose, and before and after the third dose. Our findings evinced a remarkable initial cellular and humoral response to each vaccine dose, although a progressive decline suggests the potential need for long-term booster doses. Age analysis showed significantly higher immunoglobulin G levels in the younger group after the first dose administration, although these differences were not maintained in the following doses. Preserving cellular immunity could assure long-lasting protection against SARS-CoV-2 infection.

Indexed as

covid-19humoral responselymphocyte subpopulationssars-cov-2vaccination

Identifiers

PMID39759737
PMCPMC11700304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.