ArticleCureus2024
Association Between Serum Antinuclear Antibody and Polycystic Ovarian Syndrome in Reproductive Women Aged 18 to 35 Years: A Quest for an Autoimmune Marker.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Antinuclear Antibodies in Polycystic Ovary Syndrome: A Systematic Review of Observational Studies.International journal of molecular sciences · 2025Pooled it
- Autoimmune Thyroid Disease and Female Fertility: Does Anti-TPO Accelerate Ovarian Aging?Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPolycystic ovarian syndrome (PCOS) is a heterogeneous endocrinal physiological disorder characterized by chronic oligo-ovulation or an-ovulation, hyperandrogenism, and polycystic morphology in ovaries on transvaginal or abdominal ultrasound. Hyperandrogenism and insulin resistance are already well-documented pathophysiological mechanisms in PCOS. Besides this, autoimmunity has been hypothesized in its pathogenesis. Studies regarding the association between PCOS and autoimmunity have yielded contradictory results. There is scarce data regarding the prevalence of autoimmune markers among PCOS women from India. Therefore, this study was done to find the relationship between antinuclear antibody (ANA) positivity and PCOS.
objectiveTo determine the prevalence of ANA positivity in women with PCOS and to see the association of Serum antinuclear antibodies ANA with clinical, hormonal, and biochemical parameters of PCOS.
methodsThis cross-sectional study was done in the Obstetrics and Gynaecology department, All India Institute of Medical Sciences (AIIMS), Raipur, for a period of 18 months. The study population consisted of a total of 140 women aged 18-35 years and were equally divided into the 'PCOS 'and 'Control' groups. The 'PCOS' group consisted of 70 women with a diagnosis of PCOS as per revised 2003 Rotterdam criteria. The 'Control' group consisted of 70 healthy women with no PCOS. History-taking and clinical examinations were done on all women. History taking included medical, surgical, menstrual, and any other relevant history. Clinical examinations included general physical examination and anthropometry like height, weight, build, body mass index (BMI), waist-to-hip ratio (WHI), etc. We did Hirsutism scoring with a modified Ferriman-Gallaway scoring system. Blood samples were taken for ANA estimation and biochemical and hormonal essay.
resultsThe prevalence of ANA positivity in PCOS and the control group was 10% and 4.3%, respectively (not statistically significant). There was no significant association found between ANA positivity and PCOS (p-value=-0.326). There was no significant association found between ANA positivity and modified Ferriman-Gallwey scores, serum testosterone levels and HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) levels.
conclusionThere was no statistically significant association between ANA positivity and PCOS, but we found an increased prevalence of ANA in the PCOS group as compared to the non-PCOS group.Though our study did not find a significant association between ANA positivity and modified Ferriman Gallwey score, serum testosterone levels, and HOMA-IR levels, we found a significant increase in anti-TPO levels in ANA-positive PCOS women. We conclude that the increased prevalence of ANA positivity in PCOS could be an indicator of autoimmunity.
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