Evidence map›Paper›PMID 39759665›Full record

ArticleCureus2024

Concurrent Onset of Osimertinib-Induced Heart Failure and Metronidazole-Induced Encephalopathy During Brain Abscess Treatment: A Report of a Rare Case.

Emi Mikami, Kosuke Hashimoto, Kyoichi Kaira, Atsuto Mouri, Yu Miura, Ayako Shiono, Ou Yamaguchi, Hisao Imai, Hiroshi Kagamu

Abstract readCase Reports
In one paragraph

Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emi MikamiClinical Training Center, Saitama Medical University International Medical Center, Hidaka, JPN.
Kosuke HashimotoRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Kyoichi KairaRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Atsuto MouriRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Yu MiuraRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Ayako ShionoRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Ou YamaguchiRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Hisao ImaiRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.
Hiroshi KagamuRespiratory Medicine, Saitama Medical University International Medical Center, Hidaka, JPN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of concurrent onset of osimertinib-induced heart failure and metronidazole-induced encephalopathy during treatment of a brain abscess. A 78-year-old female with lung adenocarcinoma presented with neurological symptoms and was diagnosed with a brain abscess. During treatment, she developed heart failure and encephalopathy, linked to osimertinib and metronidazole, respectively. Following the discontinuation of these drugs, her symptoms gradually improved. This case underscores the need for careful monitoring of adverse drug reactions, especially in patients with significant weight loss. Regular cardiac and neurological assessments are recommended to promptly identify and manage such events.

Indexed as

encephalopathyheart failuremetronidazoleosimertinibweight loss

Identifiers

PMID39759665
PMCPMC11698534

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.