ArticleCureus2024
A Case of Ossified Tissue Misdiagnosed as Amyloid Deposits by Congo Red Stain and Birefringence.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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4 authors.
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Abstract
Pulmonary amyloidosis is diagnosed by identifying amyloid deposits using Congo red stain (CR) and birefringence under polarized light. However, collagen fibers can also produce similar staining results, complicating diagnosis. We report a case of a 55-year-old male patient with lung opacities, initially suspected to have amyloidosis based on CR positivity and green birefringence. Thoracoscopic biopsy revealed pulmonary ossification (PO) rather than amyloidosis. The parallel alignment of lamellar bone fibers likely caused false-positive CR findings and birefringence. This case underscores the need for careful differentiation between bone tissue and amyloid deposits. Misdiagnosis can lead to unnecessary treatments, especially when the actual condition requires only conservative management, as in PO. Awareness of PO as a mimic of amyloidosis is crucial, especially in cases lacking other systemic symptoms or calcification.
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