ArticleHeliyon2024
Spatial and temporal evaluation of iodine uptake and radiodensity in meniscus tissue using contrast-enhanced micro-CT.
Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Proteomic study for the prediction ofHistochemistry and cell biology · 2026Article
- Stepwise micro-CT analysis of sample processing effects on the 3D morphology of human intervertebral discs.Osteoarthritis and cartilage open · 2026Article
- Review
- Toward functional integration of 3D-printed meniscal scaffolds: A materials-driven systematic review of preclinical evidence and translational framework.Journal of experimental orthopaedics · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale and objective: The visualization of soft tissues, like the meniscus, through X-ray micro-computed tomography (micro-CT), requires the use of contrast agents (CAs). While other studies have investigated CA diffusion in fibrocartilagineous tissues, this work aimed to optimize iodine staining protocols for meniscal tissue that improve their visualization by micro-CT. Specific objectives included evaluating the diffusion of CAs within meniscal samples over time, assessing volume changes due to staining, and identifying the iodine ions absorbed by the tissue. Materials and methods: Water-based and PBS-based Lugol solutions (KI Results: Results indicated volumetric shrinkage and increased radiodensity within the first days of staining, with diffusion primarily occurring from the periphery of the meniscus. UV-visible spectroscopy identified two iodide ions in the CA solution (I Conclusion: This study demonstrated the utility of iodine-based CAs and micro-CT technique for visualizing and investigating the spatial and temporal iodine diffusion within the meniscal tissue of sheep and pigs. The findings of this study have important implications for using iodine-based CAs in imaging analyses of the meniscus and offer potentially valuable insights into the diffusion patterns of iodine in fibrocartilagineous tissues.
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Registered trials
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