Genetic Variation in MiRNA Processing Machinery Genes and Susceptibility to Colorectal Cancer in the Iranian Population.

Marzieh Mobaraki, Hamid Asadzadeh Aghdaei, Seyed Abdolhamid Angaji, Ehsan Nazemalhosseini-Mojarad, Sedigheh Arbabian

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Article in Iranian journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Marzieh MobarakiDepartment of Biology, Faculty of Biological Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran.

Hamid Asadzadeh AghdaeiBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Seyed Abdolhamid AngajiDepartment of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Hesarak, Tehran, Iran.

Ehsan Nazemalhosseini-MojaradDepartment of Cancer, Gastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Sedigheh ArbabianDepartment of Biology, Faculty of Biological Sciences, Islamic Azad University, North Tehran Branch, Tehran, Iran.

Funding

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6 · The paper itself

Abstract

Background: We aimed to elucidate the potential correlation between single-nucleotide polymorphisms (SNPs) in miRNA machinery genes and colorectal cancer (CRC) risk in an Iranian cohort. Methods: We conducted a robust case-control study involving 507 participants, which included 213 patients diagnosed with CRC and 294 healthy controls at Research Institute for Gastroenterology and Liver Diseases in Tehran Province, Iran in 2018. The study focused on genotyping four specific SNPs, Results: Notably, our investigation revealed the significant inverse association between the C/C genotype of rs197412 in the Conclusion: Our study provides compelling evidence that SNPs within miRNA processing genes significantly contribute to susceptibility to CRC among the Iranian population. Our research not only contributes to the growing body of miRNA-related genetic studies but also opens avenues for population-specific risk assessment and personalized medicine approaches in cancer therapy.

Indexed as

Colorectal cancerGeneticsSingle-nucleotide polymorphisms

Identifiers

PMID39759214

PMCPMC11693808

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