Evidence map›Paper›PMID 39759173›Full record

Articlenpj women's health2025

Quantitative and longitudinal assessment of human placental inflammation using diffusion basis spectrum imaging.

Zhexian Sun, Wenjie Wu, Zezhen Xiang, Hansong Gao, Weina Ju, Cherilyn Uhm, Ian S Hagemann, Pamela K Woodard, Nanbert Zhong, Alison G Cahill and 2 more

Abstract read
In one paragraph

Article in npj women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhexian SunDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO USA.
Wenjie WuDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO USA.
Zezhen XiangDepartment of Obstetrics and Gynecology, Washington University School of Medicine, Washington University in St Louis, St Louis, MO USA.
Hansong GaoDepartment of Obstetrics and Gynecology, Washington University School of Medicine, Washington University in St Louis, St Louis, MO USA.
Weina JuNew York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY USA.
Cherilyn UhmNew York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY USA.
Ian S HagemannDepartment of Obstetrics and Gynecology, Washington University School of Medicine, Washington University in St Louis, St Louis, MO USA.
Pamela K WoodardDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO USA.
Nanbert ZhongNew York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY USA.
Alison G CahillDepartment of Women's Health, Dell Medical School, University of Texas, Austin, TX USA.
Qing WangMallinckrodt Institute of Radiology, Washington University School of Medicine, Washington University in St Louis, St Louis, MO USA.
Yong WangDepartment of Biomedical Engineering, Washington University in St Louis, St Louis, MO USA.

Funding

Quantitative Endogenous MRI Imaging of Neuroinflammation in ADR01AG074909 · NIA · WASHINGTON UNIVERSITY · PI QING WANG · 2022 to 2026
$3.7M
NIA NIH HHS R01 AG074909
6 · The paper itself

Abstract

Besides exchanging nutrients, gases, and wastes, placenta is an intermediary between maternal and fetal immune systems. However, no method exists to safely image and monitor placental inflammation during pregnancy. We customized a Magnetic Resonance Imaging (MRI) method, diffusion basis spectrum imaging (DBSI), to measure immune cells in placenta. We validated placental DBSI in simulations and ex-vivo specimens, then applied it to 202 MRI scans from 82 patients whose placentas were classified as non-inflammation (

Indexed as

Reproductive disorders

Identifiers

PMID39759173
PMCPMC11698687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.