Evidence map›Paper›PMID 39759117›Full record

ArticleGenes & diseases2025

Fibrous scaffolds loaded with BMSC-derived apoptotic vesicles promote wound healing by inducing macrophage polarization.

Xudong Su, Jianye Yang, Zhenghao Xu, Li Wei, Shuhao Yang, Feilong Li, Min Sun, Yingkun Hu, Wenge He, Chen Zhao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xudong SuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jianye YangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhenghao XuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li WeiDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Shuhao YangDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Feilong LiDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Min SunDepartment of Knee Joint Sports Injury, Sichuan Provincial Orthopedic Hospital, Chengdu, Sichuan 610042, China.
Yingkun HuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wenge HeDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Chen ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li ChenDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Yonghua YuanResearch Center for Pharmacodynamic Evaluation Engineering Technology of Chongqing, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Leilei QinDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Ning HuDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages play a key role in wound healing. Dysfunction of their M0 polarization to M2 leads to disorders of the wound immune microenvironment and chronic inflammation, which affects wound healing. Regulating the polarization of M0 macrophages to M2 macrophages is an effective strategy for treating wound healing. Mesenchymal stem cells (MSCs) deliver endogenous regulatory factors via paracrine extracellular vesicles, which may play a key role in wound healing, and previous studies have shown that apoptotic bodies (ABs) are closely associated with inflammation regression and macrophage polarization. However, the specific regulatory mechanisms involved in ABs remain unknown. In the present study, we designed an MSC-AB (MSC-derived AB)-loaded polycaprolactone (PCL) scaffold, evaluated the macrophage phenotype and skin wound inflammation

Indexed as

Apoptotic bodyExtracellular vesiclesMacrophage polarizationMesenchymal stem cellsmiR-21a-5pPolycaprolactoneWound healing

Identifiers

PMID39759117
PMCPMC11697094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.