ArticleJournal of anaesthesiology, clinical pharmacology
Effect of age on the median effective dose and 95% effective dose of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation: A double-blind, up-and-down sequential method trial.
Article in Journal of anaesthesiology, clinical pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
Background and Aims: Control of the hemodynamic response during intubation is essential. To assess the effect of age on the median effective dose (ED50) and 95% effective dose (ED95) of fentanyl for blunting the hemodynamic response to intubation. Material and Methods: Patients ( Results: ED50s of fentanyl in groups 1 (20-35 years), 2 (36-50 years), 3 (51-65 years), and 4 (66-80 years) were 2 μg/kg (90% confidence interval, 1.50-2.50), 2.25 μg/kg (2.00-2.50), 1.89 μg/kg (1.54-2.21), and 1.27 μg/kg (0.72-1.82), respectively. ED95s in groups 1, 2, 3, and 4 were 2.45 μg/kg (2.32-2.96), 2.79 μg/kg (2.58-4.38), 2.44 μg/kg (2.33-3.06), and 2.70 μg/kg (2.30-5.18), respectively. There was a statistically significant incidence of cough in group 2. Conclusions: Patients aged 65-80 years required the lowest ED50 of fentanyl dose, whereas patients aged 36-50 years required the highest ED50 and ED95 dose to blunt the hemodynamic response during intubation.
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