Evidence map›Paper›PMID 39759008›Full record

ArticleiScience2024

The mesenteric adipokine SFRP5 alleviated intestinal epithelial apoptosis improving barrier dysfunction in Crohn's disease.

Xiaofeng Zhang, Lugen Zuo, Xue Song, Wenjing Zhang, Zi Yang, Zhiyuan Wang, Yibing Guo, Sitang Ge, Lian Wang, Yueyue Wang and 3 more

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In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xiaofeng ZhangDepartment of Central Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Lugen ZuoAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu, China.
Xue SongDepartment of Central Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Wenjing ZhangDepartment of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Zi YangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.
Zhiyuan WangClinical Medical College, Bengbu Medical University, Bengbu, China.
Yibing GuoClinical Medical College, Bengbu Medical University, Bengbu, China.
Sitang GeAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu, China.
Lian WangDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China.
Yueyue WangAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu, China.
Zhijun GengDepartment of Central Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Jing LiAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu, China.
Jianguo HuAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-related Diseases, Bengbu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hypertrophic mesenteric adipose tissue (htMAT) of Crohn disease (CD) participates in inflammation through the expression of adipokines, but the exact mechanism of this action in the intestine is unknown. Here, we analyzed the expression of secreted frizzled-related protein 5 (SFRP5), an adipokine with cytoprotective effects, in htMAT and its role in CD. The results of this study revealed that the level of SFPR5 increased in the diseased MAT (htMAT) of CD patients and aggregated among intestinal epithelial cells in the diseased intestine and that it could ameliorate intestinal barrier dysfunction in tumor necrosis factor alpha (TNF-α)-stimulated colonic organoids and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced mice at least in part through the inhibition of Wnt5a-mediated apoptosis in epithelial cells. This study elucidates possible mechanisms by which mesenteric adipokines influence the progression of enteritis and provides a new theoretical basis for the treatment of CD via the mesenteric pathway.

Indexed as

CancerCell biology

Identifiers

PMID39759008
PMCPMC11699250

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.