Evidence map›Paper›PMID 39759000›Full record

ArticleiScience2024

miR-193b-365 microcluster downstream of

Asha Iyer, Lee O Vaasjo, Verl B Siththanandan, Rajan K C, Abbigail Thurmon, Mauren Akumuo, Victoria Lu, Chelsea Nnebe, Ramesh Nair, Maria J Galazo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Asha IyerDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Lee O VaasjoNeuroscience program, Tulane Brain Institute, Tulane University, New Orleans, LA 70118 USA.
Verl B SiththanandanDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Rajan K CDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118 USA.
Abbigail ThurmonDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118 USA.
Mauren AkumuoDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118 USA.
Victoria LuDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Chelsea NnebeDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Ramesh NairStanford Center for Genomics and Personalized Medicine, Stanford, CA 94305, USA.
Maria J GalazoNeuroscience program, Tulane Brain Institute, Tulane University, New Orleans, LA 70118 USA.
Suzanne TharinDepartment of Neurosurgery, Stanford University, Stanford, CA 94305, USA.

Funding

VECTOR COREP30NS069375 · NINDS · STANFORD UNIVERSITY · PI STEINBERG, GARY K · 2011 to 2019
$6.3M
Molecular Determinants for In vivo Functional Reprogramming of Cortical Output Neurons and CircuitsR01NS128106 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI Maria J Galazo · 2022 to 2026
$1.9M
miR-409-3p controls corticospinal development: therapies for spinal cord injury.K08NS091531 · NINDS · STANFORD UNIVERSITY · PI THARIN, SUZANNE AUDREY · 2015 to 2019
$694k
Manipulation of neuron identity towards in-vivo circuit reprogramming in the cerebral cortexF99NS134203 · NINDS · TULANE UNIVERSITY OF LOUISIANA · PI VAASJO, LEE O · 2023 to 2023
$49k
NINDS NIH HHS F99 NS134203NINDS NIH HHS K08 NS091531NINDS NIH HHS P30 NS069375NINDS NIH HHS R01 NS128106
6 · The paper itself

Abstract

Different neuron types develop characteristic axonal and dendritic arborizations that determine their inputs, outputs, and functions. Expression of fate-determinant transcription factors is essential for specification of their distinct identities. However, the mechanisms downstream of fate-determinant factors coordinating different aspects of neuron identity are not understood. Specifically, how distinct projection neurons develop appropriate dendritic arbors that determine their inputs is unknown. Here, we investigate this question in corticospinal and callosal projection neurons. We identified a mechanism linking the corticospinal/corticofugal identity gene

Indexed as

Biological sciencesDevelopmental neuroscienceEpigenetics

Identifiers

PMID39759000
PMCPMC11697703

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.