Evidence map›Paper›PMID 39758987›Full record

ArticleiScience2024

Bivalent SMAC mimetic APG-1387 reduces HIV reservoirs and limits viral rebound in humanized mice.

Jaspreet Jain, Tram N Q Pham, Sharmin Begum, Maria Carmen Romero-Medina, Nicolas Bellini, Yuanyi Li, Frédéric Dallaire, Kathie Béland, Natasha Patey, Jean V Guimond and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jaspreet JainInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Tram N Q PhamInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Sharmin BegumInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Maria Carmen Romero-MedinaInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Nicolas BelliniInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Yuanyi LiCHU Sainte-Justine Azrieli Research Center, Montréal, QC H3T 1C5, Canada.
Frédéric DallaireInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.
Kathie BélandCHU Sainte-Justine Azrieli Research Center, Montréal, QC H3T 1C5, Canada.
Natasha PateyCHU Sainte-Justine Azrieli Research Center, Montréal, QC H3T 1C5, Canada.
Jean V GuimondCentre de Santé et de Services Sociaux Jeanne-Mance, Montréal, QC H2X 1K6, Canada.
Élie HaddadDepartment of Microbiology, Infectiology and Immunology, Université de Montréal, Montréal, QC H3T 1J4, Canada.
Yifan ZhaiAscentage Pharma (Suzhou) Co., Ltd., Suzhou, Jiangsu 215000, China.
Éric A CohenInstitut de Recherches Cliniques de Montréal (IRCM), Montréal, QC H2W 1R7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Latent viral reservoirs (VRs) represent a main barrier to HIV cure. Thus, developing new approaches that can purge and eliminate VRs paves the path toward achieving an HIV-1 cure. APG-1387, a bivalent SMAC mimetic (SM), efficiently reactivates latent HIV expression in T cell line models and enhances active caspase 3 expression, a condition that typically leads to apoptosis. In primary CD4

Indexed as

Biological sciencesImmunologyNatural sciencesVirology

Identifiers

PMID39758987
PMCPMC11699618

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.