Evidence map›Paper›PMID 39758904›Full record

ArticleRSC advances2025

A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine.

Akira Takagi, Ippei Takashima, Kensuke Okuda

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Akira TakagiLaboratory of Bioorganic & Natural Products Chemistry, Kobe Pharmaceutical University 4-19-1, Motoyamakita, Higashinada Kobe Hyogo 658-8558 Japan okuda@kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0002-5797-7440
Ippei TakashimaLaboratory of Bioorganic & Natural Products Chemistry, Kobe Pharmaceutical University 4-19-1, Motoyamakita, Higashinada Kobe Hyogo 658-8558 Japan okuda@kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0002-0749-2349
Kensuke OkudaLaboratory of Bioorganic & Natural Products Chemistry, Kobe Pharmaceutical University 4-19-1, Motoyamakita, Higashinada Kobe Hyogo 658-8558 Japan okuda@kobepharma-u.ac.jp.ORCID https://orcid.org/0000-0002-3768-0965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluorogenic probes containing the β-ketoester structure were developed for selective hydrazine detection. The probe equipped with a cyclopropane moiety, having reduced steric hindrance, showed a higher reaction rate than its dimethyl counterpart. In live cell imaging, the probe detects intracellular hydrazine with minimal cytotoxicity. This study introduces a promising tool for hydrazine detection that may assist in reducing the risks associated with hydrazine exposure in various applications.

Identifiers

PMID39758904
PMCPMC11697295

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.