ArticleTurkish journal of biology = Turk biyoloji dergisi2024
The cumulative effect of ellagic acid and carnosic acid attenuates oxidative events during diabetic wound healing: in different applications and on different days.
Article in Turkish journal of biology = Turk biyoloji dergisi, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Sustained intravitreal delivery of carnosic acid by RADA16 peptide hydrogel protects the retina in acute ocular hypertension.Scientific reports · 2026Article
- Use of Psidium guajava fruit suspension may prevent treatment relapse following orthodontic tooth movement in Wistar rat model.The Saudi dental journal · 2026Article
- Investigating the protective and therapeutic potential of new generation antioxidant combinations in the brain: an experimental aging model.Biogerontology · 2026Article
- An Insight on Ellagic Acid Formulations for the Management of Skin Diseases.Molecules (Basel, Switzerland) · 2025Review
- Article
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Authors and funding
4 authors.
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Abstract
Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds ellagic acid and carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats. Materials and methods: Diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment groups. Ellagic acid and carnosic acid in combination were applied topically and as oral gavage to the full-thickness excisional wounds of all animals except for those in the control group. We investigated oxidative events with malondialdehyde, glutathione, nitric oxide, protein carbonyl, collagen spectrophotometrically, and matrix metalloproteinase 2 and 9 and advanced oxidation protein product levels using ELISA. Results: The combination of ellagic acid and carnosic acid decreased malondialdehyde, nitric oxide, protein carbonyl, advanced oxidation protein product, and metalloproteinase 9 levels and increased the rate of wound contraction and collagen levels in the diabetic wound healing model. Conclusion: The combined use of ellagic acid and carnosic acid showed a synergistic effect, enhanced wound healing, and decreased oxidative stress. This combination may provide effective therapy for chronic nonhealing wounds that occur as a complication of diabetes.
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